ArticleBiomaterials2015
Design and validation of a clinical-scale bioreactor for long-term isolated lung culture.
Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Bioimpedance measurements of fibrotic and acutely injured lung tissues.Acta biomaterialia · 2025Article
- Lung Tissue Engineering: Toward a More Deliberate Approach.ACS biomaterials science & engineering · 2022Review
- A Two-Step Bioreactor for Decellularized Lung Epithelialization.Cells, tissues, organs · 2021Article
- Human-scale lung regeneration based on decellularized matrix scaffolds as a biologic platform.Surgery today · 2020Review
- Bioengineering the Blood-gas Barrier.Comprehensive Physiology · 2020Review
- Functional role of glycosaminoglycans in decellularized lung extracellular matrix.Acta biomaterialia · 2020Article
- A Fully Automated High-Throughput Bioreactor System for Lung Regeneration.Tissue engineering. Part C, Methods · 2018Article
- Acellular human lung scaffolds to model lung disease and tissue regeneration.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Perfusion decellularization of a human limb: A novel platform for composite tissue engineering and reconstructive surgery.PloS one · 2018Article
- Essential design considerations for the resazurin reduction assay to noninvasively quantify cell expansion within perfused extracellular matrix scaffolds.Biomaterials · 2017Article
- Lung regeneration: steps toward clinical implementation and use.Current opinion in anaesthesiology · 2017Review
- hPSC-derived lung and intestinal organoids as models of human fetal tissue.Developmental biology · 2016Review
- Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ.Respiratory research · 2016Review
- Regenerative potential of human airway stem cells in lung epithelial engineering.Biomaterials · 2016Article
- Comparative Decellularization and Recellularization of Wild-Type and Alpha 1,3 Galactosyltransferase Knockout Pig Lungs: A Model for Ex Vivo Xenogeneic Lung Bioengineering and Transplantation.Tissue engineering. Part C, Methods · 2016Article
- Tissue Engineering and Regenerative Medicine 2015: A Year in Review.Tissue engineering. Part B, Reviews · 2016Review
- Engineering a microcirculation for perfusion control of ex vivo-assembled organ systems: Challenges and opportunities.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The primary treatment for end-stage lung disease is lung transplantation. However, donor organ shortage remains a major barrier for many patients. In recent years, techniques for maintaining lungs ex vivo for evaluation and short-term (<12 h) resuscitation have come into more widespread use in an attempt to expand the donor pool. In parallel, progress in whole organ engineering has provided the potential perspective of patient derived grafts grown on demand. As both of these strategies advance to more complex interventions for lung repair and regeneration, the need for a long-term organ culture system becomes apparent. Herein we describe a novel clinical scale bioreactor capable of maintaining functional porcine and human lungs for at least 72 h in isolated lung culture (ILC). The fully automated, computer controlled, sterile, closed circuit system enables physiologic pulsatile perfusion and negative pressure ventilation, while gas exchange function, and metabolism can be evaluated. Creation of this stable, biomimetic long-term culture environment will enable advanced interventions in both donor lungs and engineered grafts of human scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.