Evidence map›Paper›PMID 25818365›Full record

ReviewBiochimica et biophysica acta2015

Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.

Josette M Northcott, Jason J Northey, J Matthew Barnes, Valerie M Weaver

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. A Case of Identity:Cancers · 2019
    Review
  7. Article
  8. Prospero homeobox 1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Josette M NorthcottDepartment of Surgery, Surgical Research Laboratory, UCSF, 1001 Potrero Ave, San Francisco, CA 94143, USA.
Jason J NortheyDepartment of Surgery, Center for Bioengineering and Tissue Regeneration, UCSF, 513 Parnassus Ave, San Francisco, CA 94143, USA.
J Matthew BarnesDepartment of Surgery, Center for Bioengineering and Tissue Regeneration, UCSF, 513 Parnassus Ave, San Francisco, CA 94143, USA.
Valerie M WeaverDepartment of Surgery, Center for Bioengineering and Tissue Regeneration, UCSF, 513 Parnassus Ave, San Francisco, CA 94143, USA; Department of Anatomy, UCSF, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA, USA; UCSF Helen Diller Comprehensive Cancer Center, UCSF, San Francisco, CA, USA. Electronic address: Valerie.Weaver@ucsfmedctr.org.

Funding

TRANS-NETWORK PROJECTSU54CA143836 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI LIPHARDT, JAN T. · 2009 to 2014
$15.1M
TGF BETA SUPPRESSION AND PROMOTION OF MAMMARY CARCINOMASR01CA085492 · NCI · VANDERBILT UNIVERSITY · PI MOSES, HAROLD L, WEAVER, VALERIE MARIE · 2000 to 2015
$6.4M
The vascular niche in glioma propagation and resistance to therapyU54CA163155 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BERGERS, GABRIELE, WEAVER, VALERIE MARIE · 2011 to 2015
$4.4M
Studies of Protein GlycosylationR01GM066047 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BERTOZZI, CAROLYN · 2002 to 2014
$3.8M
Role of Fibroblasts, Myeloid Cells and Matrix in PDACU01CA151925 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KALLURI, RAGHU, MOSES, HAROLD L · 2010 to 2014
$3.2M
A biophysical stromal basis for radiation sensitivity in ductal carcinoma in situR01CA174929 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PARK, CATHERINE C, WEAVER, VALERIE MARIE · 2014 to 2018
$3.1M
Tension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9M
Environmental Effect on the Mammary Gland across the LifespanU01ES019458 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 2010 to 2014
$2.5M
Collagen remodeling and tumor progressionR01CA138818 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEAVER, VALERIE MARIE · 2010 to 2014
$2.0M
Advanced Methods to Evaluate Extracellular Matrix and Crosslinking in the Tumor MR33CA183685 · NCI · UNIVERSITY OF COLORADO DENVER · PI HANSEN, KIRK C, WEAVER, VALERIE MARIE · 2014 to 2016
$1.1M
Interplay between intrinsic and extrinsic force and glioma aggressionF32CA174319 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARNES, JAMES MATTHEW · 2013 to 2015
$120k
NCI NIH HHS F32 CA174319NCI NIH HHS F32CA174319NCI NIH HHS R01 CA085492NCI NIH HHS R01 CA138818NCI NIH HHS R01 CA174929NCI NIH HHS R01 CA192914NCI NIH HHS R33 CA183685NCI NIH HHS U01 CA151925NCI NIH HHS U54 CA143836NCI NIH HHS U54 CA163155NIEHS NIH HHS U01 ES019458NIGMS NIH HHS R01 GM066047
6 · The paper itself

Abstract

Tumor cells exist in a constantly evolving stromal microenvironment composed of vasculature, immune cells and cancer-associated fibroblasts, all residing within a dynamic extracellular matrix. In this review, we examine the biochemical and biophysical interactions between these various stromal cells and their matrix microenvironment. While the stroma can alter tumor progression via multiple mechanisms, we emphasize the role of homeobox genes in detecting and modulating the mechanical changes in the microenvironment during tumor progression.

Indexed as

CarcinogenesisExtracellular MatrixGene Expression Regulation, NeoplasticHomeodomain ProteinsHumansNeoplasmsStromal CellsTumor MicroenvironmentHomeodomain ProteinsExtracellular matrixHomeobox genesStiffnessStromal cellsTumor microenvironment

Identifiers

PMID25818365
PMCPMC4433566

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.