Evidence map›Paper›PMID 25818028›Full record

ReviewVirology2015

Nuclear proteins hijacked by mammalian cytoplasmic plus strand RNA viruses.

Richard E Lloyd

Abstract readReview
In one paragraph

Review in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. T-Cell Intracellular Antigen 1-Like Protein in Physiology and Pathology.International journal of molecular sciences · 2022
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Seneca Valley virus 3CVirulence · 2021
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Richard E LloydDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States. Electronic address: rlloyd@bcm.edu.

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
TRANSGENIC MOUSE MODELS TO STUDY OVARIAN FUNCTIONU54HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 1998 to 2013
$19.9M
Translation Regulation by Enterovirus ProteinaseR01AI050237 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI LLOYD, RICHARD E · 2002 to 2022
$6.9M
GROWTH AND DIFFERENTIATION IN EUKARYOTEST32HD007495 · NICHD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KINTNER, CHRISTOPHER ROBERT · 1995 to 2009
$1.6M
Translation Regulation by Enterovirus ProteinaseR56AI050237 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI LLOYD, RICHARD E · 2007 to 2007
$384k
TRANSGENIC ANIMAL--COREP30HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI GLASSER, STANLEY R · 1985 to 1997
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NCI NIH HHS CA125123NCI NIH HHS P30 CA125123NCI NIH HHS P30CA1251230NIAID NIH HHS AI50237NIAID NIH HHS R01 AI050237NIAID NIH HHS R56 AI050237NICHD NIH HHS HD007495NICHD NIH HHS P30 HD007495NICHD NIH HHS T32 HD007495NICHD NIH HHS U54 HD007495NIDDK NIH HHS DK56338NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Plus strand RNA viruses that replicate in the cytoplasm face challenges in supporting the numerous biosynthetic functions required for replication and propagation. Most of these viruses are genetically simple and rely heavily on co-opting cellular proteins, particularly cellular RNA-binding proteins, into new roles for support of virus infection at the level of virus-specific translation, and building RNA replication complexes. In the course of infectious cycles many nuclear-cytoplasmic shuttling proteins of mostly nuclear distribution are detained in the cytoplasm by viruses and re-purposed for their own gain. Many mammalian viruses hijack a common group of the same factors. This review summarizes recent gains in our knowledge of how cytoplasmic RNA viruses use these co-opted host nuclear factors in new functional roles supporting virus translation and virus RNA replication and common themes employed between different virus groups.

Indexed as

Host-Pathogen InteractionsProtein BiosynthesisVirus ReplicationCytoplasmNuclear ProteinsRNA VirusesNuclear ProteinsCoronavirusEnterovirusFlavivirusG3BP1Hepatitis C virushnRNP A1hnRNP ChnRNP KhnRNP MLa proteinNorovirusNSAPPCBP2PoliovirusPTBRNA helicase ARNA virusSRp20Tia1/TIARUNR

Identifiers

PMID25818028
PMCPMC4426963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.