ReviewMolecular and cellular endocrinology2015
Childhood obesity, bone development, and cardiometabolic risk factors.
Review in Molecular and cellular endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin K and Glucose Metabolism in Children at Risk for Diabetes
Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes
Who cites it
59 citing papers in PubMed, 6 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Obesity and long bone fractures in children. Systematic review.Archives of orthopaedic and trauma surgery · 2026Pooled it
- Examining adolescents' obesogenic behaviors on structured days: a systematic review and meta-analysis.International journal of obesity (2005) · 2022Pooled it
- State-of-the-art of measures of the obesogenic environment for children.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- TheAdipocyte · 2020Pooled it
- Effects of total fat intake on bodyweight in children.The Cochrane database of systematic reviews · 2018Pooled it
- Effects of total fat intake on bodyweight in children.The Cochrane database of systematic reviews · 2018Pooled it
- Insulin Resistance Negatively Influences the Muscle-Dependent IGF-1-Bone Mass Relationship in Premenarcheal Girls.The Journal of clinical endocrinology and metabolism · 2016Trial
- Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity.Nature communications · 2026Article
- Association between lean mass, fat mass, and waist circumference with bone mineral density in Mexican children and adolescents: a cross-sectional study.European journal of pediatrics · 2025Article
- The Role of Nutraceuticals and Probiotics in Addition to Lifestyle Intervention in the Management of Childhood Obesity-Part 2: Comorbidities.Nutrients · 2025Review
- The "Burden" of Childhood Obesity on Bone Health: A Look at Prevention and Treatment.Nutrients · 2025Review
- A new perspective on bone development in vitamin D deficiency-associated obese children.Scientific reports · 2024Article
- Do cardiometabolic risk factors mediate the relationship between body composition and bone mineral content in South Indian children aged 5 to 16 years?European journal of clinical nutrition · 2024Article
- What is the disease burden from childhood and adolescent obesity?: a narrative review.Journal of Yeungnam medical science · 2024Article
- The role of bone health in low-velocity fractures and the effects of obesity on the growing skeleton.Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- Review
- Sports and Weight Control in Children.Cureus · 2024Review
- Mendelian randomization shows causal effects of birth weight and childhood body mass index on the risk of frailty.Frontiers in public health · 2024Article
- Breastfeeding is associated with reduced risks of central obesity and hypertension in young school-aged children: a large, population-based study.International breastfeeding journal · 2023Article
- Longitudinal weight status and academic achievement in elementary schoolchildren in the United States.International journal of obesity (2005) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Osteoporosis and obesity are both major public health concerns. It has long been considered that these are distinct disorders rarely found in the same individual; however, emerging evidence supports an important interaction between adipose tissue and the skeleton. Whereas overweight per se may augment bone strength, animal studies suggest that the metabolic impairment that accompanies obesity is detrimental to bone. Obesity during childhood, a critical time for bone development, likely has profound and lasting effects on bone strength and fracture risk. This notion has received little attention in children and results are mixed, with studies reporting that bone strength development is enhanced or impaired by obesity. Whether obesity is a risk factor for osteoporosis or childhood bone health, in general, remains an important clinical question. Here, we will focus on clarifying the controversial relationships between childhood obesity and bone strength development, and provide insights into potential mechanisms that may regulate the effect of excess adiposity on bone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.