ArticleJournal of biomechanics2015
A continuous fiber distribution material model for human cervical tissue.
Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- A finite element model of pregnancy derived from maternal sonography: effect of uterine and cervical structural properties on cervical mechanical loading.bioRxiv : the preprint server for biology · 2026Article
- The Role of Biomechanical Regulation in Physiological and Pathological Pregnancy: From Mechanotransduction to Clinical Implications.International journal of biological sciences · 2026Review
- Risk factors for spontaneous preterm birth are mediated through changes in cervical length.Communications medicine · 2025Article
- Collagen turnover during cervical remodeling involves both intracellular and extracellular collagen degradation pathways†.Biology of reproduction · 2025Article
- A finite porous-viscoelastic model capturing mechanical behavior of human cervix under multi-step spherical indentation.Journal of the mechanical behavior of biomedical materials · 2023Article
- Bioengineering and the cervix: The past, current, and future for addressing preterm birth.Current research in physiology · 2023Review
- Extracellular Matrix Rigidity Modulates Human Cervical Smooth Muscle Contractility-New Insights into Premature Cervical Failure and Spontaneous Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Anisotropic Material Characterization of Human Cervix Tissue Based on Indentation and Inverse Finite Element Analysis.Journal of biomechanical engineering · 2019Article
- Engineering and women's health: a slow start, but gaining momentum.Interface focus · 2019Review
- Quantitative Ultrasound Parameters Based on the Backscattered Echo Power Signal as Biomarkers of Cervical Remodeling: A Longitudinal Study in the Pregnant Rhesus Macaque.Ultrasound in medicine & biology · 2019Article
- High-speed collagen fiber modeling and orientation quantification for optical coherence tomography imaging.Optics express · 2019Article
- Cervical alterations in pregnancy.Best practice & research. Clinical obstetrics & gynaecology · 2018Review
- Characterization of the collagen microstructural organization of human cervical tissue.Reproduction (Cambridge, England) · 2018Article
- The pathophysiology of human premature cervical remodeling resulting in spontaneous preterm birth: Where are we now?Seminars in perinatology · 2017Review
- In vivo Raman spectral analysis of impaired cervical remodeling in a mouse model of delayed parturition.Scientific reports · 2017Article
- A Parameterized Ultrasound-Based Finite Element Analysis of the Mechanical Environment of Pregnancy.Journal of biomechanical engineering · 2017Article
- Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography.Journal of biomedical optics · 2016Article
- Investigating the mechanical function of the cervix during pregnancy using finite element models derived from high-resolution 3D MRI.Computer methods in biomechanics and biomedical engineering · 2016Article
- Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Women.PloS one · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
The uterine cervix during pregnancy is the vital mechanical barrier which resists compressive and tensile loads generated from a growing fetus. Premature cervical remodeling and softening is hypothesized to result in the shortening of the cervix, which is known to increase a woman׳s risk of preterm birth. To understand the role of cervical material properties in preventing preterm birth, we derive a cervical material model based on previous mechanical, biochemical and histological experiments conducted on nonpregnant and pregnant human hysterectomy cervical tissue samples. In this study we present a three-dimensional fiber composite model that captures the equilibrium material behavior of the tissue in tension and compression. Cervical tissue is modeled as a fibrous composite material, where a single family of preferentially aligned and continuously distributed collagen fibers are embedded in a compressible neo-Hookean ground substance. The total stress in the collagen solid network is calculated by integrating the fiber stresses. The shape of the fiber distribution is described by an ellipsoid where semi-principal axis lengths are fit to optical coherence tomography measurements. The composite material model is fit to averaged mechanical testing data from uni-axial compression and tension experiments, and averaged material parameters are reported for nonpregnant and term pregnant human cervical tissue. The model is then evaluated by investigating the stress and strain state of a uniform thick-walled cylinder under a compressive stress with collagen fibers preferentially aligned in the circumferential direction. This material modeling framework for the equilibrium behavior of human cervical tissue serves as a basis to determine the role of preferentially-aligned cervical collagen fibers in preventing cervical deformation during pregnancy.
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