ArticleBMJ (Clinical research ed.)2015
Use of perioperative hydroxyethyl starch 6% and albumin 5% in elective joint arthroplasty and association with adverse outcomes: a retrospective population based analysis.
Article in BMJ (Clinical research ed.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 63 citations in OpenAlex.
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- Preoperative High Sleep Quality Predicts Further Decrease in Length of Stay after Total Joint Arthroplasty under Enhanced Recovery Short-stay Program: Experience in 604 Patients from a Single Team.Orthopaedic surgery · 2022Article
- Incidence and risk factors associated with human albumin administration following total joint arthroplasty: a multicenter retrospective study.Journal of orthopaedic surgery and research · 2021Article
- Postoperative renal morbidity and mortality after volume replacement with hydroxyethyl starch 130/0.4 or albumin during surgery: a propensity score-matched study.Journal of anesthesia · 2020Article
- Renal Morbidity of 6% Hydroxyethyl Starch 130/0.4 in 9000 Propensity Score Matched Pairs of Surgical Patients.Anesthesia and analgesia · 2020Article
- Are Histological Examinations of Arthroplasty Specimens Performed Consistently Across the Country? A Large Database Study.Clinical orthopaedics and related research · 2019Article
- New Advances in the Treatment of Acute Pancreatitis.Current treatment options in gastroenterology · 2019Review
- Acute Kidney Injury in Patients Undergoing Total Hip Arthroplasty: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2019Article
- Comparison of hydroxyethyl starch regulatory summaries from the Food and Drug Administration and the European Medicines Agency.Journal of pharmaceutical policy and practice · 2017Article
- Fluid resuscitation practice patterns in intensive care units of the USA: a cross-sectional survey of critical care physicians.Perioperative medicine (London, England) · 2016Article
- Effects of different types of fluid resuscitation for hemorrhagic shock on splanchnic organ microcirculation and renal reactive oxygen species formation.Critical care (London, England) · 2015Article
- An analysis of surgical and anaesthetic factors affecting skin graft viability in patients admitted to a Burns Intensive Care Unit.Scars, burns & healingArticle
- Perioperative colloid choice and bleeding in patients undergoing musculoskeletal surgery: An observational administrative database study.International journal of critical illness and injury scienceArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether the perioperative use of hydroxyethyl starch 6% and albumin 5% in elective joint arthroplasties are associated with an increased risk for perioperative complications.
designRetrospective cohort study of population based data between 2006 and 2013.
settingData from 510 different hospitals across the United States participating in the Premier Perspective database.
participants1,051,441 patients undergoing elective total hip and knee arthroplasties. EXPOSURES: Perioperative fluid resuscitation with hydroxyethyl starch 6% or albumin 5%, or neither.
main outcome measuresAcute renal failure and thromboembolic, cardiac, and pulmonary complications.
resultsCompared with patients who received neither colloid, perioperative fluid resuscitation with hydroxyethyl starch 6% or albumin 5% was associated with an increased risk of acute renal failure (odds ratios 1.23 (95% confidence interval 1.13 to 1.34) and 1.56 (1.36 to 1.78), respectively) and most other complications. A recent decrease in hydroxyethyl starch 6% use was noted, whereas that of albumin 5% increased.
conclusionsSimilar to studies in critically ill patients, we showed that use of hydroxyethyl starch 6% was associated with an increased risk of acute renal failure and other complications in the elective perioperative orthopedic setting. This increased risk also applied to albumin 5%. These findings raise questions regarding the widespread use of these colloids in elective joint arthroplasty procedures.
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