Evidence map›Paper›PMID 25816881›Full record

ArticleNanomedicine (London, England)2015

Electrodeposited gels prepared from protein alloys.

Yinan Lin, Siran Wang, Ying Chen, Qianrui Wang, Kelly A Burke, Elise M Spedden, Cristian Staii, Anthony S Weiss, David L Kaplan

Abstract read
In one paragraph

Article in Nanomedicine (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yinan LinDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Siran Wang
Ying Chen
Qianrui Wang
Kelly A Burke
Elise M Spedden
Cristian Staii
Anthony S Weiss
David L Kaplan

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Craniofacial Tissue EngineeringR01DE016525 · NIDCR · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VUNJAK-NOVAKOVIC, GORDANA · 2005 to 2017
$5.5M
Electrotherapeutic strategies for connective tissue repairR01AR061988 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI HUNG, CLARK T., KAPLAN, DAVID L. · 2011 to 2015
$3.3M
Multifunctional Tropoelastin-Silk Biomaterial SystemsR01EB014283 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2012 to 2015
$1.2M
NIAMS NIH HHS AR005593NIAMS NIH HHS AR061988NIAMS NIH HHS R01 AR061988NIBIB NIH HHS EB014283NIBIB NIH HHS P41 EB002520NIBIB NIH HHS R01 EB014283NIDCR NIH HHS R01 DE016525
6 · The paper itself

Abstract

aimSilk-tropoelastin alloys, composed of recombinant human tropoelastin and regenerated Bombyx mori silk fibroin, are an emerging, versatile class of biomaterials endowed with tunable combinations of physical and biological properties. Electrodeposition of these alloys provides a programmable means to assemble functional gels with both spatial and temporal controllability. MATERIALS &

methodsTropoelastin-modified silk was prepared by enzymatic coupling between tyrosine residues. Hydrogel coatings were electrodeposited using two wire electrodes. RESULTS & DISCUSSION: Mechanical characterization and in vitro cell culture revealed enhanced adhesive capability and cellular response of these alloy gels as compared with electrogelled silk alone.

conclusionThese electro-depositable silk-tropoelastin alloys constitute a suitable coating material for nanoparticle-based drug carriers and offer a novel opportunity for on-demand encapsulation/release of nanomedicine.

Indexed as

AnimalsBiocompatible MaterialsBiomechanical PhenomenaCell AdhesionCells, CulturedCoated Materials, BiocompatibleDrug CarriersElectrochemical TechniquesFibroinsGelsHumansHuman Umbilical Vein Endothelial CellsMagnetic Resonance SpectroscopyMaterials TestingNanocapsulesNanoconjugatesBiocompatible MaterialsCoated Materials, BiocompatibleDrug CarriersFibroinsGelsNanocapsulesNanoconjugatesTropoelastinTyrosinedityrosine bondelectrodepositionenzymatic couplingprotein alloysilksol–geltissue adhesivetropoelastin

Identifiers

PMID25816881
PMCPMC4382808

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.