Observational studyClinical nephrology2015
Prevalence and predictors of aortic dilation as a novel cardiovascular complication in children with end-stage renal disease.
Observational study in Clinical nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- A(nother) plea for better management of post-transplant cardiovascular morbidity.Pediatric nephrology (Berlin, Germany) · 2024Article
- Aortic Dilatation in Children and Young People With ADPKD.Kidney international reports · 2024Article
- Echocardiogram screening in pediatric dialysis and transplantation.Pediatric nephrology (Berlin, Germany) · 2023Review
- Bacterial metabolites and cardiovascular risk in children with chronic kidney disease.Molecular and cellular pediatrics · 2021Review
- Cardiovascular Disease Risk Factors in Chronic Kidney Disease in Children.Seminars in nephrology · 2021Review
- Dilatation of the aorta in children with advanced chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Management of dyslipidemia in pediatric renal transplant recipients.Pediatric nephrology (Berlin, Germany) · 2021Review
- Aortic dilatation in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Article
- Aortic dilatation in children with mild to moderate chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Article
- Cardiovascular risk factors in children on dialysis: an update.Pediatric nephrology (Berlin, Germany) · 2020Review
- Arterial Hypertension and Unusual Ascending Aortic Dilatation in a Neonate With Acute Kidney Injury: Mechanistic Computer Modeling.Frontiers in physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCardiovascular disease is the leading cause of death in children with end-stage renal disease (ESRD). Isolated aortic dilation (AD) is rare in children. We aimed to determine the prevalence and the risk factors for AD in children with ESRD. METHODS AND STUDY
designWe reviewed records of all ESRD patients followed mat our institution from January 2007 to October 2012. AD was defined as Z-score > 2 in the dimension of at least one of the following echocardiographic aortic parameters: annulus, root at the sinus, sino-tubular junction, or ascending aorta.
resultsThe records of 78 patients on dialysis and 19 kidney transplant recipients were available. 30 patients (30.9%) had AD. Multivariate analysis revealed independent associations of AD with body mass index (BMI) Z-score (OR = 0.52, 95% confidence interval (CI): 0.35 - 0.78) and ESRD secondary to glomerular disease (OR = 4.58, 95% CI: 1.45 - 14.46). We developed a classification and regression tree (CART) model to identify patients at low vs. high AD risk. Our model classified 62 patients of the cohort (64%) to be high- or lowrisk, with a positive predictive value of 89% and a negative predictive value of 100%.
conclusionOur data suggest that AD, as a possible marker of aortopathy and early aneurysm formation, is a novel and prevalent cardiovascular complication in ESRD children. Glomerular disease and low BMI Zscore appear to be potent predictors. CART modeling helps identify high-risk children, potentially guiding decisions regarding targeted echocardiographic evaluations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.