Evidence map›Paper›PMID 25816354›Full record

Trial reportPloS one2015

Small-quantity lipid-based nutrient supplements, regardless of their zinc content, increase growth and reduce the prevalence of stunting and wasting in young burkinabe children: a cluster-randomized trial.

Sonja Y Hess, Souheila Abbeddou, Elizabeth Yakes Jimenez, Jérôme W Somé, Stephen A Vosti, Zinéwendé P Ouédraogo, Rosemonde M Guissou, Jean-Bosco Ouédraogo, Kenneth H Brown

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 82 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 15 pooled it
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00944281 nacompletednot on this map

A Randomized, Double-blind, Controlled Trial in Rural Burkina Faso to Determine the Optimal Amount of Zinc to Include in a Lipid-based Nutrient Supplement (LNS). Part of the iLiNS Study

TypeinterventionalSponsorUniversity of California, DavisRan2010 to 2014Enrolled3,220ConditionsMalnutritionArmsLNS-Zn5, LNS-Zn10, LNS-Zn0, Suppl-Zn5
NCT07540793 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of 7-day vs 1-day Packaging of Small Quantity Lipid-based Nutrition Supplementation (SQ-LNS)

TypeinterventionalSponsorUniversity of California, San FranciscoRan2026 to 2026Enrolled100ConditionsPrevention, Malnutrition, Child, NutritionArms7dp SQ-LNS, 1dp SQ-LNS
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 15 syntheses or guidelines pooled it, 141 citations in OpenAlex.

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  14. Oral zinc for treating diarrhoea in children.The Cochrane database of systematic reviews · 2016
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sonja Y HessProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA, United States of America.
Souheila AbbeddouProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA, United States of America.
Elizabeth Yakes JimenezNutrition Program, Department of Individual, Family and Community Education, University of New Mexico, Albuquerque, NM, United States of America.
Jérôme W SoméProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA, United States of America; Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
Stephen A VostiAgricultural and Resource Economics, University of California Davis, Davis, CA, United States of America.
Zinéwendé P OuédraogoInstitut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
Rosemonde M GuissouInstitut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
Jean-Bosco OuédraogoInstitut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
Kenneth H BrownProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA, United States of America.
University of California, Davis · USInstitut de Recherche en Sciences de la Santé · BFUniversity of New Mexico · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledSmall-quantity lipid-based nutrient supplements (SQ-LNS) are promising home fortification products, but the optimal zinc level needed to improve growth and reduce morbidity is uncertain. We aimed to assess the impact of providing SQ-LNS with varied amounts of zinc, along with illness treatment, on zinc-related outcomes compared with standard care. In a placebo-controlled, cluster-randomized trial, 34 communities were stratified to intervention (IC) or non-intervention cohorts (NIC). 2435 eligible IC children were randomly assigned to one of four groups:1) SQ-LNS without zinc, placebo tablet; 2) SQ-LNS containing 5mg zinc, placebo tablet; 3) SQ-LNS containing 10mg zinc, placebo tablet; or 4) SQ-LNS without zinc and 5mg zinc tablet from 9–18 months of age. During weekly morbidity surveillance, oral rehydration salts were provided for reported diarrhea and antimalarial therapy for confirmed malaria. Children in NIC (n = 785) did not receive SQ-LNS, tablets, illness surveillance or treatment. At 9 and 18 months, length, weight and hemoglobin were measured in all children. Reported adherence was 97 ± 6% for SQ-LNS and tablets. Mean baseline hemoglobin was 89 ± 15g/L. At 18 months, change in hemoglobin was greater in IC than NIC (+8 vs -1g/L, p<0.0001), but 79.1% of IC were still anemic (vs. 91.1% in NIC). Final plasma zinc concentration did not differ by group. During the 9-month observation period, the incidence of diarrhea was 1.10 ± 1.03 and of malaria 0.54 ± 0.50 episodes per 100 child-days, and did not differ by group. Length at 18 months was significantly greater in IC compared to NIC (77.7 ± 3.0 vs. 76.9 ± 3.4 cm; p<0.001) and stunting prevalence was significantly lower in IC (29.3%) than NIC (39.3%; p<0.0001), but did not differ by intervention group within IC. Wasting prevalence was also significantly lower in IC (8.7%) than in NIC (13.5%; p = 0.0003). Providing SQ-LNS daily with or without zinc, along with malaria and diarrhea treatment, significantly increased growth and reduced stunting, wasting and anemia prevalence in young children.

trial registrationClinicalTrials.gov NCT00944281.

Indexed as

Dietary SupplementsBurkina FasoFemaleGrowth DisordersHumansInfantLipidsMaleWasting SyndromeZincLipidsZinc

Identifiers

PMID25816354
PMCPMC4376671
OpenAlexW2037580111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.