Evidence map›Paper›PMID 25816299›Full record

ArticlePloS one2015

Direct medical cost of type 2 diabetes in singapore.

Charmaine Shuyu Ng, Matthias Paul Han Sim Toh, Yu Ko, Joyce Yu-Chia Lee

Registry-linked trialAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07252700 (Preventing Diabetes), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07252700 narecruitingnot on this mapstarted 2025, after this paper: background citation

Preventing Diabetes: Impact of an EMR-Based Intervention for Enhanced Pre-Diabetes Management in Primary Care

TypeinterventionalSponsorLynette GohRan2025 to 2028Enrolled6,000ConditionsPre Diabetes, Diabetes (DM)ArmsElectronic Medical Record-Based Clinical Decision Support
3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Epidemiology and Burden of Peripheral Artery Disease in People With Type 2 Diabetes: A Systematic Literature Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Cost of Illness Analysis of Type 2 Diabetes Mellitus: The Findings from a Lower-Middle Income Country.International journal of environmental research and public health · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Characteristics of Type-2 Diabetics Who are Prone to High-Cost Medical Care Expenses by Bayesian Network.International journal of environmental research and public health · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Charmaine Shuyu NgDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Matthias Paul Han Sim TohInformation Management, Central Regional Health Office, National Healthcare Group, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Yu KoSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Joyce Yu-Chia LeeDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the chronic nature of diabetes along with their complications, they have been recognised as a major health issue, which results in significant economic burden. This study aims to estimate the direct medical cost associated with type 2 diabetes mellitus (T2DM) in Singapore in 2010 and to examine both the relationship between demographic and clinical state variables with the total estimated expenditure. The National Healthcare Group (NHG) Chronic Disease Management System (CDMS) database was used to identify patients with T2DM in the year 2010. DM-attributable costs estimated included hospitalisations, accident and emergency (A&E) room visits, outpatient physician visits, medications, laboratory tests and allied health services. All charges and unit costs were provided by the NHG. A total of 500 patients with DM were identified for the analyses. The mean annual direct medical cost was found to be $2,034, of which 61% was accounted for by inpatient services, 35% by outpatient services, and 4% by A&E services. Independent determinants of total costs were DM treatments such as the use of insulin only (p<0.001) and the combination of both oral medications and insulin (p=0.047) as well as having complications such as cerebrovascular disease (p<0.001), cardiovascular disease (p=0.002), peripheral vascular disease (p=0.001), and nephropathy (p=0.041). In this study, the cost of DM treatments and DM-related complications were found to be strong determinants of costs. This finding suggests an imperative need to address the economic burden associated with diabetes with urgency and to reorganise resources required to improve healthcare costs.

Indexed as

Cost of IllnessAgedDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleHospitalizationHumansInpatientsInsulinMaleMiddle AgedOutpatientsPhysiciansSingaporeInsulin

Identifiers

PMID25816299
PMCPMC4376523

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.