ArticlePLoS neglected tropical diseases2015
Anthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of Schistosoma mansoni.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Imidazole Alkaloids Epiisopilosine and Epiisopiloturine Attenuate Acetaminophen-Induced Liver Toxicity in Mice via Autophagy Modulation and Anti-Inflammatory Effects.Journal of biochemical and molecular toxicology · 2026Article
- Preclinical evaluation of Senna alata leaf extract against Hymenolepis diminuta: a promising natural anthelmintic solution.BMC complementary medicine and therapies · 2026Article
- Evaluation of the prophylactic and therapeutic efficacies of mucus and tissue nucleoproteins extracted fromJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Therapeutic Potential of Natural Products in the Treatment ofMolecules (Basel, Switzerland) · 2023Review
- Neolignans isolated from Saururus cernuus L. (Saururaceae) exhibit efficacy against Schistosoma mansoni.Scientific reports · 2022Article
- Structure-based virtual screening and molecular dynamics of potential inhibitors targeting sodium-bile acid co-transporter of carcinogenic liver fluke Clonorchis sinensis.PLoS neglected tropical diseases · 2022Article
- Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs.Molecules (Basel, Switzerland) · 2021Review
- In vitro and in vivo evaluation of cnicin from blessed thistle (Centaurea benedicta) and its inclusion complexes with cyclodextrins against Schistosoma mansoni.Parasitology research · 2021Article
- H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies.Parasites & vectors · 2020Article
- Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?RSC medicinal chemistry · 2020Review
- Promethazine exhibits antiparasitic propertiesAntimicrobial agents and chemotherapy · 2019Article
- Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis.EBioMedicine · 2019Article
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- Epiisopilosine alkaloid has activity against Schistosoma mansoni in mice without acute toxicity.PloS one · 2018Article
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- The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases.Molecules (Basel, Switzerland) · 2016Review
- Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.PLoS neglected tropical diseases · 2016Article
- Taurine drinking ameliorates hepatic granuloma and fibrosis in mice infected with Schistosoma japonicum.International journal for parasitology. Drugs and drug resistance · 2016Article
- ULTRASTRUCTURAL CHANGES IN Schistosoma mansoni MALE WORMS AFTER in vitro INCUBATION WITH THE ESSENTIAL OIL OF Mentha x villosa Huds.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomiasis is a serious disease currently estimated to affect more that 207 million people worldwide. Due to the intensive use of praziquantel, there is increasing concern about the development of drug-resistant strains. Therefore, it is necessary to search for and investigate new potential schistosomicidal compounds. This work reports the in vivo effect of the alkaloid epiisopiloturine (EPI) against adults and juvenile worms of Schistosoma mansoni. EPI was first purified its thermal behavior and theoretical solubility parameters charaterised. In the experiment, mice were treated with EPI over the 21 days post-infection with the doses of 40 and 200 mg/kg, and 45 days post-infection with single doses of 40, 100 and 300 mg/kg. The treatment with EPI at 40 mg/kg was more effective in adult worms when compared with doses of 100 and 300 mg/kg. The treatment with 40 mg/kg in adult worms reduced parasite burden significantly, lead to reduction in hepatosplenomegaly, reduced the egg burden in faeces, and decreased granuloma diameter. Scanning electron microscopy revealed morphological changes to the parasite tegument after treatment, including the loss of important features. Additionally, the in vivo treatment against juvenile with 40 mg/kg showed a reduction of the total worm burden of 50.2%. Histopathological studies were performed on liver, spleen, lung, kidney and brain and EPI was shown to have a DL50 of 8000 mg/kg. Therefore EPI shows potential to be used in schistosomiasis treatment. This is the first time that schistosomicidal in vivo activity of EPI has been reported.
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