Evidence map›Paper›PMID 25815983›Full record

ArticleCell2015

Cultivating healthy growth and nutrition through the gut microbiota.

Sathish Subramanian, Laura V Blanton, Steven A Frese, Mark Charbonneau, David A Mills, Jeffrey I Gordon

Abstract read
In one paragraph

Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 162 citations in OpenAlex.

  1. Trial
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  4. Vaginal Seeding: Is There Any Positive Effect in Canine C-Sections?Animals : an open access journal from MDPI · 2025
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sathish SubramanianCenter for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
Laura V BlantonCenter for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
Steven A FreseDepartments of Food Science & Technology and Viticulture & Enology, University of California, Davis, Davis, CA 95616, USA.
Mark CharbonneauCenter for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
David A MillsDepartments of Food Science & Technology and Viticulture & Enology, University of California, Davis, Davis, CA 95616, USA.
Jeffrey I GordonCenter for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA. Electronic address: jgordon@wustl.edu.
Washington University in St. Louis · USUniversity of California, Davis · US

Funding

Trace the flow of genes in the gut microbiome of obese and lean twin pairsP01DK078669 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 2007 to 2018
$16.0M
REGULATION OF GENE EXPRESSION - SMALL INTESTINER01DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI JEFFREY I GORDON, ANDREI L OSTERMAN · 1986 to 2026
$6.5M
GUT MICROBIOTA AND OBESITY: STUDIES IN GNOTOBIOTIC MICER01DK070977 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I, HETTICH, ROBERT L. · 2005 to 2020
$6.3M
REGULATION OF GENE EXPRESSION IN THE SMALL INTESTINER37DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 1993 to 2015
$4.0M
Mechanism of Activation of Probiotic Bifidobacteria by Prebiotic Milk GlycansR01AT007079 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2012 to 2016
$2.2M
NCCIH NIH HHS R01 AT007079NIDDK NIH HHS DK078669NIDDK NIH HHS DK30292NIDDK NIH HHS DK70977NIDDK NIH HHS P01 DK078669NIDDK NIH HHS R01 DK030292NIDDK NIH HHS R01 DK070977NIDDK NIH HHS R37 DK030292
6 · The paper itself

Abstract

Microbiota assembly is perturbed in children with undernutrition, resulting in persistent microbiota immaturity that is not rescued by current nutritional interventions. Evidence is accumulating that this immaturity is causally related to the pathogenesis of undernutrition and its lingering sequelae. Preclinical models in which human gut communities are replicated in gnotobiotic mice have provided an opportunity to identify and predict the effects of different dietary ingredients on microbiota structure, expressed functions, and host biology. This capacity sets the stage for proof-of-concept tests designed to deliberately shape the developmental trajectory and configurations of microbiota in children representing different geographies, cultural traditions, and states of health. Developing these capabilities for microbial stewardship is timely given the global health burden of childhood undernutrition, the effects of changing eating practices brought about by globalization, and the realization that affordable nutritious foods need to be developed to enhance our capacity to cultivate healthier microbiota in populations at risk for poor nutrition.

Indexed as

Child DevelopmentMicrobiotaAnimalsChildChild Nutritional Physiological PhenomenaFemaleGastrointestinal TractHumansMaternal-Fetal ExchangePregnancy

Identifiers

PMID25815983
PMCPMC4440586
OpenAlexW1972081874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.