ArticleAnalytical chemistry2015
Sheath-flow microfluidic approach for combined surface enhanced Raman scattering and electrochemical detection.
Article in Analytical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Ultrasensitive SERS detectionThe Analyst · 2026Article
- Sheath-enhanced concentration and on-chip detection of bacteria from an extremely low-concentration level.Lab on a chip · 2025Article
- Machine Learning-Assisted Surface-Enhanced Raman Spectroscopy Detection for Environmental Applications: A Review.Environmental science & technology · 2024Review
- Digital surface enhanced Raman spectroscopy for quantifiable single molecule detection in flow.The Analyst · 2024Article
- Raman and Surface-Enhanced Raman Scattering Detection in Flowing Solutions for Complex Mixture Analysis.Annual review of analytical chemistry (Palo Alto, Calif.) · 2024Review
- Electrochemical sensing of B-complex vitamins: current challenges and future prospects with microfluidic integration.RSC advances · 2024Review
- A 3D printed sheath flow interface for surface enhanced Raman spectroscopy (SERS) detection in flow.The Analyst · 2024Article
- Potential Dependent Spectroelectrochemistry of Electrofluorogenic Dyes on Indium-Tin Oxide.Electrochemical science advances · 2022Article
- A numerical study on the closed packed array of gold discs as an efficient dual mode plasmonic tweezers.Scientific reports · 2021Article
- A wafer-scale fabrication method for three-dimensional plasmonic hollow nanopillars.Nanoscale advances · 2021Article
- Surface-enhanced Raman spectroscopy: benefits, trade-offs and future developments.Chemical science · 2020Review
- Application of microfluidic chip technology in pharmaceutical analysis: A review.Journal of pharmaceutical analysis · 2019Article
- Electrochemical Surface-Enhanced Raman Spectroscopy of Pyocyanin Secreted by Pseudomonas aeruginosa Communities.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Online Liquid Chromatography-Sheath-Flow Surface Enhanced Raman Detection of Phosphorylated Carbohydrates.Analytical chemistry · 2018Article
- Illuminating the dark metabolome to advance the molecular characterisation of biological systems.Metabolomics : Official journal of the Metabolomic Society · 2018Review
- Bioanalytical applications of surface-enhanced Raman spectroscopy:Reviews in analytical chemistry · 2017Article
- Review of SERS Substrates for Chemical Sensing.Nanomaterials (Basel, Switzerland) · 2017Review
- Time resolved and label free monitoring of extracellular metabolites by surface enhanced Raman spectroscopy.PloS one · 2017Article
- Role of Surface Adsorption in the Surface-Enhanced Raman Scattering and Electrochemical Detection of Neurotransmitters.The journal of physical chemistry. C, Nanomaterials and interfaces · 2016Article
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Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The combination of hydrodynamic focusing with embedded capillaries in a microfluidic device is shown to enable both surface enhanced Raman scattering (SERS) and electrochemical characterization of analytes at nanomolar concentrations in flow. The approach utilizes a versatile polystyrene device that contains an encapsulated microelectrode and fluidic tubing, which is shown to enable straightforward hydrodynamic focusing onto the electrode surface to improve detection. A polydimethyslsiloxane (PDMS) microchannel positioned over both the embedded tubing and SERS active electrode (aligned ∼200 μm from each other) generates a sheath flow that confines the analyte molecules eluting from the embedded tubing over the SERS electrode, increasing the interaction between the Riboflavin (vitamin B2) and the SERS active electrode. The microfluidic device was characterized using finite element simulations, amperometry, and Raman experiments. This device shows a SERS and amperometric detection limit near 1 and 100 nM, respectively. This combination of SERS and amperometry in a single device provides an improved method to identify and quantify electroactive analytes over either technique independently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.