ReviewLife (Basel, Switzerland)2015
Engineering protocells: prospects for self-assembly and nanoscale production-lines.
Review in Life (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Emergent Chemical Reactivity and Complexity of RNA Condensates.Angewandte Chemie (International ed. in English) · 2025Article
- Bacteria and cells as alternative nano-carriers for biomedical applications.Expert opinion on drug delivery · 2022Review
- Engineering and functional characterization of a proton-driven β-lactam antibiotic translocation module for bionanotechnological applications.Scientific reports · 2021Article
- Beyond natural: synthetic expansions of botanical form and function.The New phytologist · 2020Review
- Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration.ACS synthetic biology · 2020Article
- Formation of Polarized, Functional Artificial Cells from Compartmentalized Droplet Networks and Nanomaterials, Using One-Step, Dual-Material 3D-Printed Microfluidics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Design and assembly of a chemically switchable and fluorescently traceable light-driven proton pump system for bionanotechnological applications.Scientific reports · 2019Article
- Automated in vitro evolution of a translation-coupled RNA replication system in a droplet flow reactor.Scientific reports · 2018Article
- Computer-aided biochemical programming of synthetic microreactors as diagnostic devices.Molecular systems biology · 2018Article
- Bioinspired Design of Alcohol Dehydrogenase@nano TiO₂ Microreactors for Sustainable Cycling of NAD⁺/NADH Coenzyme.Nanomaterials (Basel, Switzerland) · 2018Article
- Engineering genetic circuit interactions within and between synthetic minimal cells.Nature chemistry · 2017Article
- Self-transformation and structural reconfiguration in coacervate-based protocells.Chemical science · 2016Article
- A roadmap for biocatalysis - functional and spatial orchestration of enzyme cascades.Microbial biotechnology · 2016Review
- Non-equilibrium behaviour in coacervate-based protocells under electric-field-induced excitation.Nature communications · 2016Article
- Bioinspired membrane-based systems for a physical approach of cell organization and dynamics: usefulness and limitations.Interface focus · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing ease of producing nucleic acids and proteins to specification offers potential for design and fabrication of artificial synthetic "organisms" with a myriad of possible capabilities. The prospects for these synthetic organisms are significant, with potential applications in diverse fields including synthesis of pharmaceuticals, sources of renewable fuel and environmental cleanup. Until now, artificial cell technology has been largely restricted to the modification and metabolic engineering of living unicellular organisms. This review discusses emerging possibilities for developing synthetic protocell "machines" assembled entirely from individual biological components. We describe a host of recent technological advances that could potentially be harnessed in design and construction of synthetic protocells, some of which have already been utilized toward these ends. More elaborate designs include options for building self-assembling machines by incorporating cellular transport and assembly machinery. We also discuss production in miniature, using microfluidic production lines. While there are still many unknowns in the design, engineering and optimization of protocells, current technologies are now tantalizingly close to the capabilities required to build the first prototype protocells with potential real-world applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.