ArticleeLife2015
Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- ATP synthase subunits e and g are essential for CaCell death and differentiation · 2026Article
- Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke.Nature communications · 2026Article
- Reconstitution of Membrane Proteins into Preformed Lipid Bilayers via LMNG-Mediated Auto-Insertion.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Mitochondrial fission - changing perspectives for future progress.Journal of cell science · 2025Review
- Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions.Cell death and differentiation · 2023Review
- The persistent homology of mitochondrial ATP synthases.iScience · 2023Article
- Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies.The EMBO journal · 2023Article
- Rapid and Highly Stable Membrane Reconstitution by LAiR Enables the Study of Physiological Integral Membrane Protein Functions.ACS central science · 2023Article
- The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation.Cell death and differentiation · 2022Article
- Review
- Lipid Membrane Mimetics in Functional and Structural Studies of Integral Membrane Proteins.Membranes · 2021Review
- Inhibition of the mitochondrial ATPase function by IF1 changes the spatiotemporal organization of ATP synthase.Biochimica et biophysica acta. Bioenergetics · 2021Article
- Mitochondrial Membrane Remodeling.Frontiers in bioengineering and biotechnology · 2021Review
- Looking Back to the Future of Mitochondrial Research.Frontiers in physiology · 2021Article
- Assembly of the peripheral stalk of ATP synthase in human mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cryo-EM structure of the entire mammalian F-type ATP synthase.Nature structural & molecular biology · 2020Article
- Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.Nature communications · 2020Article
- Structure of the dimeric ATP synthase from bovine mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Glucose-Induced Expression of DAPIT in Pancreatic β-Cells.Biomolecules · 2020Article
- Cardiomyocyte Maturation: New Phase in Development.Circulation research · 2020Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used a combination of electron cryo-tomography, subtomogram averaging, and electron crystallographic image processing to analyse the structure of intact bovine F(1)F(o) ATP synthase in 2D membrane crystals. ATPase assays and mass spectrometry analysis of the 2D crystals confirmed that the enzyme complex was complete and active. The structure of the matrix-exposed region was determined at 24 Å resolution by subtomogram averaging and repositioned into the tomographic volume to reveal the crystal packing. F(1)F(o) ATP synthase complexes are inclined by 16° relative to the crystal plane, resulting in a zigzag topology of the membrane and indicating that monomeric bovine heart F(1)F(o) ATP synthase by itself is sufficient to deform lipid bilayers. This local membrane curvature is likely to be instrumental in the formation of ATP synthase dimers and dimer rows, and thus for the shaping of mitochondrial cristae.
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