ArticleeLife2015
Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed, 136 citations in OpenAlex.
- Integrating and Orchestrating Multiple Components of Skeletal Muscle Injury and Regeneration.American journal of physiology. Cell physiology · 2026Article
- OscillomeR infers ultradian oscillations and targets of the Hes family.Patterns (New York, N.Y.) · 2026Article
- TDP-43 sustains satellite cells to maintain and regenerate skeletal muscle.Stem cell reports · 2026Article
- A who's who of cell types in skeletal muscle.Communications biology · 2026Review
- Activating FGFR1 restores Integrin-β1-mediated fibronectin sensing in satellite cells of aged mice.bioRxiv : the preprint server for biology · 2026Article
- Novel Four-gene Panel for Detecting Senescence-associated Cell States in Skeletal Muscle Tissue.Juntendo medical journal · 2026Article
- Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control.Cell discovery · 2024Article
- Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation.Stem cells (Dayton, Ohio) · 2024Article
- Retinoic acid signalling inhibits myogenesis by blocking MYOD translation in pig skeletal muscle cells.Animal biotechnology · 2024Article
- A novel ferroptosis-related gene signature for overall survival prediction in patients with gastric cancer.Scientific reports · 2024Article
- Asynchronous Pattern of MAPKs' Activity during Aging of Different Tissues and of Distinct Types of Skeletal Muscle.International journal of molecular sciences · 2024Article
- piR-36249 and DHX36 together inhibit testicular cancer cells progression by upregulating OAS2.Non-coding RNA research · 2023Article
- Generation of a MyoD knock-in reporter mouse line to study muscle stem cell dynamics and heterogeneity.iScience · 2023Article
- Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity.Nature reviews. Molecular cell biology · 2023Review
- Muscle stem cells get a new look: Dynamic cellular projections as sensors of the stem cell niche.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Article
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- Biological Role and Clinical Implications ofCancers · 2023Review
- P2Y1R and P2Y2R: potential molecular triggers in muscle regeneration.Purinergic signalling · 2023Review
- The transcript interactome of skeletal muscle RNA binding protein motif 3 (RBM3).Physiological reports · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population. To understand the mechanisms involved in maintaining satellite cell quiescence, we identified gene transcripts that were differentially expressed during satellite cell activation following muscle injury. Transcripts encoding RNA binding proteins were among the most significantly changed and included the mRNA decay factor Tristetraprolin. Tristetraprolin promotes the decay of MyoD mRNA, which encodes a transcriptional regulator of myogenic commitment, via binding to the MyoD mRNA 3' untranslated region. Upon satellite cell activation, p38α/β MAPK phosphorylates MAPKAP2 and inactivates Tristetraprolin, stabilizing MyoD mRNA. Satellite cell specific knockdown of Tristetraprolin precociously activates satellite cells in vivo, enabling MyoD accumulation, differentiation and cell fusion into myofibers. Regulation of mRNAs by Tristetraprolin appears to function as one of several critical post-transcriptional regulatory mechanisms controlling satellite cell homeostasis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.