ArticleThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2016
Lower brain-derived neurotrophic factor levels associated with worsening fatigue in prostate cancer patients during repeated stress from radiation therapy.
Article in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Symptom management in adult brain tumours: A literature review.Nursing open · 2023Pooled it
- Brain-Derived Neurotrophic Factor (BDNF) as a Marker of Physical Exercise or Activity Effectiveness in Fatigue, Pain, Depression, and Sleep Disturbances: A Scoping Review.Biomedicines · 2025Review
- Article
- Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors.Journal of cancer survivorship : research and practice · 2024Article
- Intradialytic cycling and cognitive training to mitigate decreased functional and physiological status in haemodialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Nordic Walking as a Non-Pharmacological Intervention for Chronic Pain and Fatigue: Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- BDNF and its signaling in cancer.Journal of cancer research and clinical oncology · 2023Review
- The temporal relation between pain and fatigue in individuals receiving treatment for chronic musculoskeletal pain.BMC musculoskeletal disorders · 2022Article
- Fatigue prevalence in men treated for prostate cancer: A systematic review and meta-analysis.World journal of clinical cases · 2021Article
- An exploratory analysis of extracellular vesicle-associated and soluble cytokines in cancer-related fatigue in men with prostate cancer.Brain, behavior, & immunity - health · 2020Article
- Reductions in Fatigue Predict Occupational Re-engagement in Individuals with Work-Related Musculoskeletal Disorders.Journal of occupational rehabilitation · 2020Article
- Induction of fatigue-like behavior by pelvic irradiation of male mice alters cognitive behaviors and BDNF expression.PloS one · 2020Article
- Psychoactive drugs influence brain-derived neurotrophic factor and neurotrophin 4/5 levels in the serum of colorectal cancer patients.Biomedical reports · 2017Article
- Psychological and Physiological Biomarkers of Neuromuscular Fatigue after Two Bouts of Sprint Interval Exercise.Frontiers in psychology · 2017Article
- Effect of fermented porcine placenta on physical fatigue in mice.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- The Etiology and management of radiotherapy-induced fatigue.Expert review of quality of life in cancer care · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesFatigue during cancer treatment is associated with depression. Neurotrophic factors play a major role in depression and stress and might provide insight into mechanisms of fatigue. This study investigated the association between plasma concentrations of three neurotrophic factors (BDNF, brain-derived neurotrophic factor; GDNF, glial-derived neurotrophic factor; and SNAPIN, soluble N-ethylmaleimide sensitive fusion attachment receptor-associated protein) and initial fatigue intensification during external beam radiation therapy (EBRT) in euthymic non-metastatic prostate cancer men.
methodsFatigue, as measured by the 13-item Functional Assessment of Cancer Therapy-Fatigue (FACT-F), and plasma neurotrophic factors were collected at baseline (prior to EBRT) and mid-EBRT. Subjects were categorized into fatigue and no fatigue groups using a > 3-point change in FACT-F scores between the two time points. Multiple linear regressions analysed the associations between fatigue and neurotrophic factors.
resultsFACT-F scores of 47 subjects decreased from baseline (43.95 ± 1.3) to mid-EBRT (38.36 ± 1.5, P < 0.001), indicating worsening fatigue. SNAPIN levels were associated with fatigue scores (r
conclusionsBaseline SNAPIN and decreasing BDNF levels may influence worsening fatigue during EBRT. Further investigations are warranted to confirm their role in the pathophysiology and therapeutics of fatigue.
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Registered trials
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