ArticlePain2015
Opioid-induced hyperalgesia in community-dwelling adults with chronic pain.
Article in Pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Lost in translation: toward clinically effective translational research.Translational psychiatry · 2025Review
- Opioid prescribing in Canada: a continued retreat from God's own medicine.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Article
- Low-dose ketamine infusion to facilitate opioid tapering in chronic non-cancer pain with opioid-use disorder: a historical cohort study.Regional anesthesia and pain medicine · 2025Article
- Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial.JMIR research protocols · 2025Article
- Contemporaneous Link Between Pain and Craving in Patients Recovering from Prescription Opioid Use Disorder During Residential Treatment.Substance use & misuse · 2025Article
- Article
- Increased Use and Large Variation in Strong Opioids and Metamizole (Dipyrone) for Minor and Major Musculoskeletal Injuries Between 2008 and 2018: An Analysis of a Representative Sample of Swiss Workers.Journal of occupational rehabilitation · 2024Article
- Factors influencing pain medication and opioid use in patients with musculoskeletal injuries: a retrospective insurance claims database study.Scientific reports · 2024Article
- Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury.Nature neuroscience · 2023Article
- Chronic pain and problematic substance use for veterans during COVID-19: the moderating role of psychological flexibility.Frontiers in psychology · 2023Article
- Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents.Cellular and molecular neurobiology · 2021Article
- Real-World Evidence in Prescription Medication Use Among U.S. Adults with Neck Pain.Pain and therapy · 2020Article
- Medical Use of Long-term Extended-release Opioid Analgesics in Commercially Insured Adults in the United States.Pain medicine (Malden, Mass.) · 2020Article
- Balancing the Risks and Benefits of Opioid Therapy: The Pill and the Pendulum.Mayo Clinic proceedings · 2019Article
- Review
- Prescription Medication Use Among Community-Based U.S. Adults With Chronic Low Back Pain: A Cross-Sectional Population Based Study.The journal of pain · 2018Article
- Linking opioid-induced hyperalgesia and withdrawal-associated injury site pain: a case report.Pain reports · 2018Article
- Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model.Canadian journal of pain = Revue canadienne de la douleur · 2018Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The hyperalgesic effects of long-term opioid use in community-dwelling adults with chronic pain have not been widely reported. Therefore, the primary aim of this study was to determine the associations between opioid use and heat pain (HP) perception in a sample of community-dwelling adults with chronic pain. The study cohort involved 187 adults (85 opioid and 102 nonopioid) with chronic pain consecutively admitted to an outpatient interdisciplinary pain treatment program. Heat pain perception was assessed using a validated quantitative sensory test method of levels. An effect of opioid use was observed for nonstandardized (P = 0.004) and standardized (P = 0.005) values of HP 5-0.5 in which values of the opioid group were lower (more hyperalgesic) compared with those of the nonopioid group. HP 5-0.5 is a measure of the slope of the line connecting HP 0.5 (HP threshold) and HP 5 (intermediate measure of HP tolerance). In univariable (P = 0.019) and multiple variable (P = 0.003) linear regression analyses (adjusted for age, sex, body mass index, work status, pain diagnosis, pain severity, depression, and pain catastrophizing), opioid use was associated with lower (more hyperalgesic) nonstandardized values of HP 5-0.5. Similarly, in univariable (P = 0.004) and multiple variable (P = 0.011) linear regression analyses (adjusted for work status, pain diagnosis, pain severity, depression, and pain catastrophizing), opioid use was associated with lower standardized values of HP 5-0.5. In this sample of community-dwelling adults, these observations suggest that long-term opioid use was associated with hyperalgesia independent of other clinical factors known to influence HP perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.