ArticleJournal of the American Chemical Society2015
Synthesis and potent antimalarial activity of kalihinol B.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Polypharmacology in malaria treatment: single drugs, multiple mechanisms, greater impact.Trends in parasitology · 2026Review
- A Divergent Synthesis of Numerous Pyrroloiminoquinone Alkaloids Identifies Promising Antiprotozoal Agents.Journal of the American Chemical Society · 2024Article
- A kalihinol analog disrupts apicoplast function and vesicular trafficking inScience (New York, N.Y.) · 2024Article
- Unified Synthesis of 2-Isocyanoallopupukeanane and 9-Isocyanopupukeanane through a "Contra-biosynthetic" Rearrangement.Angewandte Chemie (International ed. in English) · 2024Article
- Highly Diastereoselective Preparation of Tertiary Alkyl Isonitriles by Stereoinvertive Nucleophilic Substitution at a Nonclassical Carbocation.Organic letters · 2023Article
- An Enantiospecific Synthesis of Isoneoamphilectane Confirms Its Strained Tricyclic Structure.Journal of the American Chemical Society · 2023Article
- Evolution of a Short and Stereocontrolled Synthesis of (+)-7,20-Diisocyanoadociane.The Journal of organic chemistry · 2022Article
- Antimalarial Natural Products.Progress in the chemistry of organic natural products · 2022Article
- Synthetic Studies of the Rubellin Natural Products: Development of a Stereoselective Strategy and Total Synthesis of (+)-Rubellin C.The Journal of organic chemistry · 2021Article
- Total Synthesis of (+)-Rubellin C.Organic letters · 2020Article
- Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones.Journal of computer-aided molecular design · 2020Article
- Concise Formal Synthesis of the Pseudopterosins via Anionic Oxy-Cope/Transannular Michael Addition Cascade.Organic letters · 2020Article
- Nucleophilic Isocyanation.ACS omega · 2020Review
- Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists.Nature chemistry · 2020Article
- Tailoring chemoenzymatic oxidation via in situ peracids.Organic & biomolecular chemistry · 2019Article
- Concise Synthesis of the Antiplasmodial Isocyanoterpene 7,20-Diisocyanoadociane.Angewandte Chemie (International ed. in English) · 2019Article
- Stereocontrolled Synthesis of Kalihinol C.Journal of the American Chemical Society · 2017Article
- Antimalarial Properties of Simplified Kalihinol Analogues.ACS medicinal chemistry letters · 2017Article
- Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class.Journal of the American Chemical Society · 2016Article
- Marine Isonitriles and Their Related Compounds.Marine drugs · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial activity, in spite of the fact that kalihinol A is the most potent among the members of the larger family of antimalarial isocyanoterpenes. We have validated a strategy designed to access many of the kalihinanes with a 12-step enantioselective synthesis of kalihinol B, the tetrahydrofuran isomer of kalihinol A (a tetrahydropyran). Kalihinol B shows similarly high potency against chloroquine-resistant Plasmodium falciparum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.