ArticleOncoscience2015
Successful re-treatment of a relapsed V600E mutated HCL patient with low-dose vemurafenib.
Article in Oncoscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Article
- Article
- Interdigitating Dendritic Cell Tumor of Submandibular Lymph Node: Case Report and Literature Review.Iranian journal of pathology · 2021Article
- BRAF in the cross-hairs.Expert review of hematology · 2019Review
- Recent advances in understanding and managing hairy cell leukemia.F1000Research · 2018Review
- Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.Blood · 2017Article
- BRAF-mutated clear cell sarcoma is sensitive to vemurafenib treatment.Investigational new drugs · 2015Article
- Braf mutation in interdigitating dendritic cell sarcoma: a case report and review of the literature.Cancer biology & therapy · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder that accounts for 2% of all leukemia. Recent identification of the recurrent V600E BRAF mutation in a majority of HCL patients has led some teams to evaluate the clinical potential of vemurafenib, a BRAF V600 specific inhibitor in a limited number of refractory HCL patients. Recently, we published the case of an HCL patient successfully treated with a low dose of vemurafenib. Eight months after the ending of treatment this patient relapsed. We present here the successful retreatment of this patient with a second line of vemurafenib. Our data suggest for the first time that vemurafenib at the dose of 240 mg once a day could be sufficient to maintain a complete hematological remission after an initial induction treatment with low-dose vemurafenib (2 × 240 mg) daily without inducing major toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.