Evidence map›Paper›PMID 25815335›Full record

ArticleBioMed research international2015

Optical coherence tomography in patients with Chiari I malformation.

Michele Figus, Chiara Posarelli, Francesco Nasini, Paolo Perrini, Mario Miccoli, Angelo Baggiani, Antonio Ferreras, Marco Nardi

Abstract read
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Chiari 1 malformation with optic disc drusen.Neuro-ophthalmology (Aeolus Press) · 2018
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michele FigusDepartment of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0003-3211-3344
Chiara PosarelliDepartment of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0003-0222-5177
Francesco NasiniDepartment of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0001-7618-7308
Paolo PerriniDepartment of Neurosurgery 2, University of Pisa, 56124 Pisa, Italy.
Mario MiccoliDepartment of Translational Research and Advanced Technologies in Medicine and Surgery, University of Pisa, 56124 Pisa, Italy.
Angelo BaggianiDepartment of Translational Research and Advanced Technologies in Medicine and Surgery, University of Pisa, 56124 Pisa, Italy.
Antonio FerrerasMiguel Servet University Hospital, Aragon Health Sciences Institute, Zaragoza, Spain.ORCID 0000-0002-2914-2593
Marco NardiDepartment of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, 56124 Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsTo evaluate optic nerve head with spectral domain optical coherence tomography (OCT) in patients with Chiari I malformation (CMI) compared to healthy controls.

methodsCross-sectional study. OCT of the optic nerve head of 22 patients with CMI and 22 healthy controls was quantitatively analyzed. The healthy controls were matched for age and sex with the study population. Mean retinal nerve fiber layer (RNFL) thickness was calculated for both eyes; the mean thickness value was also registered for each quadrant and for each subfield of the four quadrants.

resultsCMI patients showed a reduction of the RNFL thickness in both eyes. This reduction was more statistically significant (P < 0.05) for the inferior quadrant in the right eye and in each quadrant than nasal one in the left eye.

conclusionA distress of the retinal nerve fibers could explain the observed reduction of the RNFL thickness in patients with CMI; in our series the reduction of the RNFL thickness seems lower when CMI is associated with syringomyelia.

Indexed as

Tomography, Optical CoherenceAdultArnold-Chiari MalformationFemaleHumansMaleMiddle AgedNerve FibersOptic DiskRadiographyRetinaRetinal Ganglion Cells

Identifiers

PMID25815335
PMCPMC4357022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.