ArticleFrontiers in cellular and infection microbiology2015
Census of solo LuxR genes in prokaryotic genomes.
Article in Frontiers in cellular and infection microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 90 citations in OpenAlex.
- Domain-Swapped LuxR-Type Quorum Sensing Receptors Reveal Divergent Ligand-Response Mechanisms among Homologues.Journal of the American Chemical Society · 2026Article
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- Expanding the LuxR-type receptor functional repertoire: Protein-protein interactions in quorum sensing regulation.PLoS pathogens · 2026Review
- Extracellular vesicles as structured vectors of quorum sensing signals influence aquatic microbial communities.NPJ biofilms and microbiomes · 2026Article
- Responses of rumen bacterial microflora to aflatoxin B1 challenge: potential roles of AHLs/AI-2 mediated quorum sensing.Animal microbiome · 2026Article
- Virulence regulation in the fish pathogenFrontiers in cellular and infection microbiology · 2026Review
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- The acquisition of additional control over quorum sensing regulation reduces the variability of final cell density in Burkholderia.Communications biology · 2025Article
- Targeting quorum sensing for manipulation of commensal microbiota.BMC biotechnology · 2024Review
- Synthetic Homoserine Lactone Sensors for Gram-PositiveACS synthetic biology · 2024Article
- Targeting microbial quorum sensing: the next frontier to hinder bacterial driven gastrointestinal infections.Gut microbes · 2023Review
- Microbiome engineering for bioremediation of emerging pollutants.Bioprocess and biosystems engineering · 2023Review
- LuxR402 ofFrontiers in microbiology · 2023Article
- Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells.Nature chemical biology · 2022Article
- Signal Transduction Network Principles Underlying Bacterial Collective Behaviors.Annual review of microbiology · 2022Review
- Mechanisms of Inhibition of Quorum Sensing as an Alternative for the Control ofMicroorganisms · 2022Review
- Complete Genome Analysis Reveals the Quorum Sensing-Related Spoilage Potential ofFrontiers in microbiology · 2022Article
- Dickeya Manipulates Multiple Quorum Sensing Systems to Control Virulence and Collective Behaviors.Frontiers in plant science · 2022Review
- Signs of biofilm formation in the genome ofSaudi journal of biological sciences · 2021Article
- Identification of a solo acylhomoserine lactone synthase from the myxobacterium Archangium gephyra.Scientific reports · 2021Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
luxR genes encode transcriptional regulators that control acyl homoserine lactone-based quorum sensing (AHL QS) in Gram negative bacteria. On the bacterial chromosome, luxR genes are usually found next or near to a luxI gene encoding the AHL signal synthase. Recently, a number of luxR genes were described that have no luxI genes in their vicinity on the chromosome. These so-called solo luxR genes may either respond to internal AHL signals produced by a non-adjacent luxI in the chromosome, or can respond to exogenous signals. Here we present a survey of solo luxR genes found in complete and draft bacterial genomes in the NCBI databases using HMMs. We found that 2698 of the 3550 luxR genes found are solos, which is an unexpectedly high number even if some of the hits may be false positives. We also found that solo LuxR sequences form distinct clusters that are different from the clusters of LuxR sequences that are part of the known luxR-luxI topological arrangements. We also found a number of cases that we termed twin luxR topologies, in which two adjacent luxR genes were in tandem or divergent orientation. Many of the luxR solo clusters were devoid of the sequence motifs characteristic of AHL binding LuxR proteins so there is room to speculate that the solos may be involved in sensing hitherto unknown signals. It was noted that only some of the LuxR clades are rich in conserved cysteine residues. Molecular modeling suggests that some of the cysteines may be involved in disulfide formation, which makes us speculate that some LuxR proteins, including some of the solos may be involved in redox regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.