Evidence map›Paper›PMID 25815162›Full record

ArticleChemical science

A Far-Red Emitting Probe for Unambiguous Detection of Mobile Zinc in Acidic Vesicles and Deep Tissue.

Pablo Rivera-Fuentes, Alexandra T Wrobel, Melissa L Zastrow, Mustafa Khan, John Georgiou, Thomas T Luyben, John C Roder, Kenichi Okamoto, Stephen J Lippard

Open access · diamondAbstract read
In one paragraph

Article in Chemical science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Organelle-Level Labile ZnACS sensors · 2022
    Article
  6. Article
  7. Tools and techniques for illuminating the cell biology of zinc.Biochimica et biophysica acta. Molecular cell research · 2021
    Review
  8. ZIGIR, a Granule-Specific ZnCell reports · 2020
    Article
  9. Intracellular ZnScientific reports · 2019
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Pablo Rivera-FuentesDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.
Alexandra T WrobelDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.
Melissa L ZastrowDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.
Mustafa KhanLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5.
John GeorgiouLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5.
Thomas T LuybenLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5 ; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.
John C RoderLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5 ; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.
Kenichi OkamotoLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5 ; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.
Stephen J LippardDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.
Massachusetts Institute of Technology · USToronto Public Health · CALunenfeld-Tanenbaum Research Institute · CA

Funding

Investigation of Zinc Neurochemistry by Optical Sensing and MRIR01GM065519 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NOLAN, ELIZABETH M · 2002 to 2017
$5.3M
NIGMS NIH HHS R01 GM065519
6 · The paper itself

Abstract

Imaging mobile zinc in acidic environments remains challenging because most small-molecule optical probes display pH-dependent fluorescence. Here we report a reaction-based sensor that detects mobile zinc unambiguously at low pH. The sensor responds reversibly and with a large dynamic range to exogenously applied Zn

Identifiers

PMID25815162
PMCPMC4372157
OpenAlexW1976196862

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.