ArticleEvidence-based complementary and alternative medicine : eCAM2015
Propolis Is an Efficient Fungicide and Inhibitor of Biofilm Production by Vaginal Candida albicans.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Guideline
- Advanced Propolis Delivery: Strategies for Improved Bioavailability and Therapeutic Efficacy.ACS omega · 2026Review
- Understanding the Effect of Propolis and Its Derivatives AgainstJournal of fungi (Basel, Switzerland) · 2026Review
- Stingless bee propolis: a comprehensive review of chemical constituents and health efficacy.Natural products and bioprospecting · 2025Review
- Predicting of novel homoserine dehydrogenase inhibitors againstFuture microbiology · 2024Article
- Performance of Two Extracts Derived from Propolis on Mature Biofilm Produced byAntibiotics (Basel, Switzerland) · 2022Article
- Potential inhibitory activity of phytoconstituents against black fungus:Computational toxicology (Amsterdam, Netherlands) · 2022Article
- Propolis characterization and antimicrobial activities againstSaudi journal of biological sciences · 2022Review
- Antifungal Properties of Chemically Defined Propolis from Various Geographical Regions.Microorganisms · 2022Review
- The effect of Ethanolic extract of Indonesian propolis on endothelial dysfunction and Multi Organ dysfunction syndrome in anthrax animal model.Saudi journal of biological sciences · 2022Article
- Activity of antifungal drugs and Brazilian red and green propolis extracted with different methodologies against oral isolates of Candida spp.BMC complementary medicine and therapies · 2021Article
- Antifungal Activity of Linear and Disulfide-Cyclized Ultrashort Cationic Lipopeptides Alone and in Combination with Fluconazole against VulvovaginalPharmaceutics · 2021Article
- Anticandidal Activity of Omiganan and Its Retro Analog Alone and in Combination with Fluconazole.Probiotics and antimicrobial proteins · 2021Article
- Review
- Vulvovaginal Candidosis (Excluding Mucocutaneous Candidosis): Guideline of the German (DGGG), Austrian (OEGGG) and Swiss (SGGG) Society of Gynecology and Obstetrics (S2k-Level, AWMF Registry Number 015/072, September 2020).Geburtshilfe und Frauenheilkunde · 2021Article
- Human Nails Permeation of an Antifungal Candidate Hydroalcoholic Extract from the PlantMolecules (Basel, Switzerland) · 2021Article
- The Success of Topical Treatment of Onychomycosis Seems to Be Influenced by Fungal Features.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation.Frontiers in pharmacology · 2021Review
- Microbiological and virulence aspects ofEXCLI journal · 2020Article
- Highly efficient antibiofilm and antifungal activity of green propolis against Candida species in dentistry materials.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vulvovaginal candidiasis (VVC) is one of the most common genital infections in women. The therapeutic arsenal remains restricted, and some alternatives to VVC treatment are being studied. The present study evaluated the influence of a propolis extractive solution (PES) on biofilm production by Candida albicans isolated from patients with VVC. Susceptibility testing was used to verify the minimum inhibitory concentration (MIC) of PES, with fluconazole and nystatin as controls. The biofilm formation of 29 vaginal isolates of C. albicans and a reference strain that were exposed to PES was evaluated using crystal violet staining. Colony-forming units were evaluated, proteins and carbohydrates of the matrix biofilm were quantified, and scanning electron microscopy was performed. The MIC of PES ranged from 68.35 to 546.87 μg/mL of total phenol content in gallic acid. A concentration of 546.87 μg/mL was able to cause the death of 75.8% of the isolates. PES inhibited biofilm formation by C. albicans from VVC. Besides antifungal activity, PES appears to present important antibiofilm activity on abiotic surfaces, indicating that it may have an additional beneficial effect in the treatment of VVC.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.