ArticleFrontiers in microbiology2015
Association of blaOXA-23 and bap with the persistence of Acinetobacter baumannii within a major healthcare system.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Therapeutic significance of surface-exposed virulence factors in Acinetobacter baumannii pathogenicity.Molecular biology reports · 2026Review
- Genomic analysis of Acinetobacter baumannii DUEMBL6 reveals diesel bioremediation potential and biosafety concerns.PloS one · 2026Article
- In vitro antibacterial activity of photoactivated flavonoid glycosides against Acinetobacter baumannii.AMB Express · 2024Article
- [Characteristics of drug resistance and biofilm formation in carbapenem-resistantZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Carbapenem-ResistantMicroorganisms · 2023Article
- Antimicrobial peptide 2K4L disrupts the membrane of multidrug-resistantFrontiers in microbiology · 2023Article
- Polymyxin B Heteroresistance and Adaptive Resistance in Multidrug- and Extremely Drug-Resistant Acinetobacter baumannii.Current microbiology · 2020Article
- Zur-regulated lipoprotein A contributes to the fitness of Acinetobacter baumannii.Journal of microbiology (Seoul, Korea) · 2020Article
- Article
- Molecular Detection of Carbapenemase-Encoding Genes in Multidrug-ResistantInternational journal of microbiology · 2020Article
- Whole-Genome Sequences of FiveFrontiers in microbiology · 2019Article
- A multiplex loop-mediated isothermal amplification assay for rapid screening ofBioscience reports · 2018Article
- Distribution of virulence-associated genes and antimicrobial susceptibility in clinicalOncotarget · 2018Article
- Frequency ofIranian journal of basic medical sciences · 2017Article
- PathogenicThe Journal of biological chemistry · 2017Article
- The influence of biofilm formation and multidrug resistance on environmental survival of clinical and environmental isolates of Acinetobacter baumannii.American journal of infection control · 2016Article
- Article
- Rapid dissemination of colistin and carbapenem resistant Acinetobacter baumannii in Central Greece: mechanisms of resistance, molecular identification and epidemiological data.BMC infectious diseases · 2015Article
- Prevalence of and risk factors for multidrug-resistant Acinetobacter baumannii colonization among high-risk nursing home residents.Infection control and hospital epidemiology · 2015Article
- Diversity of multi-drug resistant Acinetobacter baumannii population in a major hospital in Kuwait.Frontiers in microbiology · 2015Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesAcinetobacter baumannii is an emerging opportunistic nosocomial pathogen. Two factors that may enhance persistence in healthcare settings are antimicrobial resistance and biofilm-forming ability. The aim of this work was to determine whether A. baumannii isolates that persist in healthcare settings (endemic), can be differentiated from sporadic isolates based upon their ability to resist antibiotics and their biofilm-forming capability.
methodsTwo hundred and ninety A. baumannii isolates were isolated over 17 months in the Detroit Medical Center (DMC). The isolates were genotyped using repetitive extragenic palindromic-PCR (REP-PCR). REP-types appearing greater than 10 times during active surveillance were considered endemic. The in vitro biofilm-forming ability and antibiotic resistance profile of each isolate were evaluated. Isolates were tested for the presence of two genetic markers-one implicated in biofilm formation (bap) and the other in antibiotic resistance (blaOXA-23).
resultsOf the 290 isolates evaluated, 84% carried bap and 36% carried blaOXA-23 . Five unique REP-PCR banding-types were detected >10 times (endemic) and constituted 58% of the 290 isolates. These five endemic REP-PCR types were 5.1 times more likely than sporadic isolates to carry both bap and blaOXA-23 . Furthermore, endemic isolates were resistant to 3 more antibiotic classes, on average, than sporadic isolates and four of the five endemic REP-PCR types formed denser biofilms in vitro than sporadic isolates.
conclusionsEndemic A. baumannii isolates are more likely than sporadic isolates to possess factors that increase virulence and enhance survival within a large healthcare system.
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