ArticleFrontiers in microbiology2015
Subgingival microbiota in health compared to periodontitis and the influence of smoking.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 4 of them syntheses that pooled it.
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Who cites it
130 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Effect of Non-Surgical Periodontal Therapy on Subgingival Microbiota: A Systematic Review and Meta-Analysis.Journal of periodontal research · 2025Pooled it
- Bacteria of healthy periodontal tissues as candidates of probiotics: a systematic review.European journal of medical research · 2024Pooled it
- Benefits of Antimicrobial Photodynamic Therapy as an Adjunct to Non-Surgical Periodontal Treatment in Smokers with Periodontitis: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Human microbiome and microbiota identification for preventing and controlling healthcare-associated infections: A systematic review.Frontiers in public health · 2022Pooled it
- Personalized antibiotic selection in periodontal treatment improves clinical and microbiological outputs.Frontiers in cellular and infection microbiology · 2023Trial
- Topic Application of the ProbioticFrontiers in cellular and infection microbiology · 2020Trial
- The redefined identity ofJournal of bacteriology · 2026Review
- Subgingival Microbiome in Young Adult Cigarette Smokers, E-Cigarette Users, and Non-Smokers.Medicina (Kaunas, Lithuania) · 2026Article
- Ecological Dynamics and Functional Classification ofMicroorganisms · 2026Review
- Low-Molecular-Weight Fucoidan fromFoods (Basel, Switzerland) · 2026Article
- Dual probiotic intervention with Lactiplantibacillus plantarum Kmiate-6 and Pediococcus acidilactici Kmiate-15 improves periodontal health and oral microbiota balance in dogs.Animal microbiome · 2026Article
- Periodontal Status and Disease Activity in Psoriatic Arthritis and Psoriasis: A Cross-Sectional Study.Archives of rheumatology · 2026Article
- Host-microbiome-immune disequilibrium in oral disease: mechanisms, dysbiosis, and precision therapeutics.Frontiers in immunology · 2026Review
- Unveiling potential driver taxa in subgingival plaque and their roles in mediating periodontitis progression.Journal of oral microbiology · 2026Article
- The Interplay Between Lifestyle and Oral/Faecal Microbial Profiles Among Periodontal Disease Patients: A Cross-Sectional Study.Journal of clinical periodontology · 2026Article
- Oral Microbiome Signatures in Periodontitis and Edentulism-A Population-Based Study.Journal of periodontal research · 2025Article
- Multiple sclerosis patients exhibit oral dysbiosis with decreased early colonizers and lower hypotaurine level.NPJ biofilms and microbiomes · 2025Article
- Signature of oral microbial dysbiosis in different periodontitis risk levels.Applied microbiology and biotechnology · 2025Article
- Altered Bacteria Abundance Is Associated With Outcomes in Head and Neck Squamous Cell Carcinoma.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Genomic diversity inMicrobial genomics · 2025Article
70 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of periodontitis has traditionally been associated to a consortium of three bacterial species-the so-called "red-complex" of periodontal disease-which has been the target for most diagnostic and therapeutic strategies. However, other species have also been found to correlate with disease severity. In addition, the influence of smoking on periodontal microbiota is poorly understood. In the current manuscript, the composition of the subgingival microbiota in healthy individuals vs. patients with chronic periodontitis has been investigated using 16S pyrosequencing and the influence of smoking on periodontal composition has been examined. Subgingival bacterial communities were sampled from 82 patients: 22 non-smoking healthy controls, 28 non-smoking periodontal patients, and 32 smoking periodontal patients. Bacterial diversity was higher in periodontal patients than in healthy subjects, which could be interpreted as the consequence of a nutritionally richer environment or a reduced immune competence. Periodontal patients showed a significantly higher prevalence/relative abundance of "established" periopathogens but also other taxa whose role is not well-established and that should be targets for future research. These include Anaeroglobus, Bulleidia, Desulfobulbus, Filifactor, Mogibacterium, Phocaeicola, Schwartzia or TM7. The microbial community of smoking-associated periodontitis is less diverse and distinct from that of non-smokers, indicating that smoking has an influence on periodontal ecology. Interestingly, the high sequencing coverage allowed the detection at low proportions of periodontal pathogens in all healthy individuals, indicating that chronic periodontitis cannot be strictly considered an infectious disease but the outcome of a polymicrobial dysbiosis, where changes in the proportions of microbial consortia trigger the inflammatory and tissue-degradation responses of the host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.