ArticleFrontiers in computational neuroscience2015
Improper activation of D1 and D2 receptors leads to excess noise in prefrontal cortex.
Article in Frontiers in computational neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Lower density of calretinin-immunopositive neurons in the putamen of subjects with schizophrenia.Journal of anatomy · 2025Article
- Computational insights on asymmetricalCognitive neurodynamics · 2024Article
- The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia.Biomolecules · 2023Review
- The Role of Dopamine D3 Receptors, Dysbindin, and Their Functional Interaction in the Expression of Key Genes for Neuroplasticity and Neuroinflammation in the Mouse Brain.International journal of molecular sciences · 2023Article
- Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats.Neurotoxicity research · 2022Article
- Errors in visuospatial working memory across space and time.Scientific reports · 2021Article
- Expression of Dopamine DFrontiers in psychiatry · 2021Article
- Activation of the mGluMolecular psychiatry · 2020Article
- Spatiotemporal transformations for gaze control.Physiological reports · 2020Review
- Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise.International journal of molecular sciences · 2020Article
- Transcriptomic context ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Effect of clozapine on ketamine-induced deficits in attentional set shift task in mice.Psychopharmacology · 2017Article
- Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors.Frontiers in behavioral neuroscience · 2017Article
- Neuromodulatory Systems and Their Interactions: A Review of Models, Theories, and Experiments.Frontiers in neural circuits · 2017Review
- Psychotic Experiences and Working Memory: A Population-Based Study Using Signal-Detection Analysis.PloS one · 2016Article
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Abstract
The dopaminergic system has been shown to control the amount of noise in the prefrontal cortex (PFC) and likely plays an important role in working memory and the pathophysiology of schizophrenia. We developed a model that takes into account the known receptor distributions of D1 and D2 receptors, the changes these receptors have on neuron response properties, as well as identified circuitry involved in working memory. Our model suggests that D1 receptor under-stimulation in supragranular layers gates internal noise into the PFC leading to cognitive symptoms as has been proposed in attention disorders, while D2 over-stimulation gates noise into the PFC by over-activation of cortico-striatal projecting neurons in infragranular layers. We apply this model in the context of a memory-guided saccade paradigm and show deficits similar to those observed in schizophrenic patients. We also show set-shifting impairments similar to those observed in rodents with D1 and D2 receptor manipulations. We discuss how the introduction of noise through changes in D1 and D2 receptor activation may account for many of the symptoms of schizophrenia depending on where this dysfunction occurs in the PFC.
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