ArticleFrontiers in cellular neuroscience2015
Heat shock response and homeostatic plasticity.
Article in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death.bioRxiv : the preprint server for biology · 2024Article
- Coping with extreme heat: current exposure and implications for the future.Evolution, medicine, and public health · 2024Review
- Retinal Changes in Parkinson's Disease: A Non-invasive Biomarker for Early Diagnosis.Cellular and molecular neurobiology · 2023Review
- Exposure to heat stress leads to striking clone-specific nymph deformity in pea aphid.PloS one · 2023Article
- Are Marine Heatwaves Responsible for Mortalities of FarmedAnimals : an open access journal from MDPI · 2022Article
- Effects of heat acclimation on cardiac function in the intertidal mussel Mytilus californianus: can laboratory-based indices predict survival in the field?The Journal of experimental biology · 2022Article
- Pathophysiological Responses ofCells · 2021Article
- Reduction in seizure burden in a child with a A350V IQSEC2 mutation using heat therapy with a Jacuzzi.Clinical case reports · 2021Article
- The synthesis and characterization of Bri2 BRICHOS coated magnetic particles and their application to protein fishing: Identification of novel binding proteins.Journal of pharmaceutical and biomedical analysis · 2021Article
- Cystatin B Involvement in Synapse Physiology of Rodent Brains and Human Cerebral Organoids.Frontiers in molecular neuroscience · 2019Article
- Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments.Translational neurodegeneration · 2017Review
- Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol.Cell stress & chaperones · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock response and homeostatic plasticity are mechanisms that afford functional stability to cells in the face of stress. Each mechanism has been investigated independently, but the link between the two has not been extensively explored. We explore this link. The heat shock response enables cells to adapt to stresses such as high temperature, metabolic stress and reduced oxygen levels. This mechanism results from the production of heat shock proteins (HSPs) which maintain normal cellular functions by counteracting the misfolding of cellular proteins. Homeostatic plasticity enables neurons and their target cells to maintain their activity levels around their respective set points in the face of stress or disturbances. This mechanism results from the recruitment of adaptations at synaptic inputs, or at voltage-gated ion channels. In this perspective, we argue that heat shock triggers homeostatic plasticity through the production of HSPs. We also suggest that homeostatic plasticity is a form of neuroprotection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.