ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of "Aging," "Life Span," and "Longevity".
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A meta-analysis of genome-wide association studies identifies multiple longevity genes.Nature communications · 2019Pooled it
- APOE Alleles and Extreme Human Longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Pooled it
- Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Pooled it
- Limitations and risks of meta-analyses of longevity studies.Mechanisms of ageing and development · 2017Pooled it
- Western Hunter-Gatherer genetic ancestry contributes to human longevity in the Italian population.GeroScience · 2026Article
- Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging.GeroScience · 2026Article
- Pathway analysis of cognitive resilience factors and cognitive function in the Long Life Family Study (LLFS).Neuropsychology · 2026Observational
- Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families.bioRxiv : the preprint server for biology · 2025Article
- SNP rs6543176 is associated with extreme human longevity but increased risk for cancer.GeroScience · 2025Article
- Race and ethnicity dynamics in survival to 100 years in the United States.Journal of internal medicine · 2025Article
- Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles.Nature communications · 2023Article
- A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants.International journal of molecular sciences · 2022Article
- Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring.GeroScience · 2022Article
- Protective Effects of Familial Longevity Decrease With Age and Become Negligible for Centenarians.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Current Trends and Approaches to the Search for Genetic Determinants of Aging and Longevity.Russian journal of genetics · 2022Article
- Effect of longevity genetic variants on the molecular aging rate.GeroScience · 2021Article
- Article
- Improved selection of participants in genetic longevity studies: family scores revisited.BMC medical research methodology · 2021Article
- Footprints in the Sand: Deep Taxonomic Comparisons in Vertebrate Genomics to Unveil the Genetic Programs of Human Longevity.Frontiers in genetics · 2021Review
- Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity.Aging cell · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The lack of a formal definition of human longevity continues to generate confusion about its genetic and nongenetic determinants. In order to characterize how differences in birth year cohorts and percentiles of survival are associated with familial contribution to variation in survival, we estimated sibling relative risk of living to increasingly rare percentiles of survival based on a dataset of 1,917 validated sibships each containing at least one individual living to age 90 years. About 1,042 of the sibships included at least one individual who survived to age 100 and 511 included at least one individual who survived to age 105 and older. We show that sibling relative risk increases with older ages, sex, and earlier birth year cohorts of the proband and siblings of male 90-year-olds (5th percentile of survival) have 1.73 (95% CI: 1.5; 2.0) times the chance of living to age 90, while siblings of both male and female probands who survived to age 105 years (~0.01 percentile of survival) have 35.6 (95%CI: 15.1; 67.7) times the chance of living to age 105 compared with population controls. These results emphasize the importance of consistently defining the longevity phenotype in terms of rarity of survival for appropriate comparisons across studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.