Trial reportBlood2015
Energy balance and fitness in adult survivors of childhood acute lymphoblastic leukemia.
Trial report in Blood, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 53 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Determination of Sarcopenia Risk and Related Factors in Pediatric Oncological Patients
Who cites it
53 citing papers in PubMed, 7 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Skeletal muscle health in childhood cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Total energy expenditure measured using doubly labeled water in adults with major chronic diseases: a systematic review.The American journal of clinical nutrition · 2024Pooled it
- Physical capacity in children and adolescents with newly diagnosed cancer: A systematic review and meta-analysis.Pediatric blood & cancer · 2024Pooled it
- Physical and functional performance assessment in pediatric oncology: a systematic review.Pediatric research · 2022Pooled it
- Whole-body vibration in children with disabilities demonstrates therapeutic potentials for pediatric cancer populations: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Pooled it
- Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Pooled it
- Health-related quality of life of survivors of childhood acute lymphoblastic leukemia: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Pooled it
- Attention and executive functioning in children and adolescents treated for high-risk acute lymphoblastic leukemia: A report from the Children's Oncology Group (COG).Pediatric blood & cancer · 2024Trial
- Children's physical activity behavior following a supervised physical activity program in pediatric oncology.Journal of cancer research and clinical oncology · 2020Trial
- Weekly physical activity trajectories in short- and long-term survivors of childhood cancer: the PACCS and SURfit studies.Journal of cancer survivorship : research and practice · 2026Article
- Self-reported physical fitness domains and perceptions of exercise and fatigue among childhood cancer survivors.JSAMS plus · 2026Article
- Brain senescence drives sarcopenia-like transcriptomic remodeling in skeletal muscle.GeroScience · 2026Article
- Association of neuropathy, sarcopenia and physical function in acute lymphoblastic leukemia survivors with chemotherapy alone.Journal of cancer survivorship : research and practice · 2026Article
- Physical Therapy Surveillance in Children with Acute Lymphoblastic Leukemia: A Quality Improvement Initiative.Pediatric reports · 2026Article
- Parent Perspectives on Physical Therapy for Their Child with Acute Lymphoblastic Leukemia:Current oncology (Toronto, Ont.) · 2026Article
- Investigating fine and gross motor deficits in pediatric patients off therapy for acute lymphoblastic leukemia.Annals of medicine · 2025Article
- New insights into total and resting energy expenditure using state-of-the-art methods in cancer survivors: a cross-sectional study.The American journal of clinical nutrition · 2025Article
- Movement efficiency in survivors of childhood acute lymphoblastic leukemia: a report from the St. Jude lifetime cohort study.Journal of cancer survivorship : research and practice · 2025Article
- Reduced Lower Body Muscular Strength and Endurance among Adult Survivors of Childhood Cancer.Medicine and science in sports and exercise · 2025Article
- Sarcopenic obesity in survivors of childhood acute lymphoblastic leukemia: prevalence, risk factors, and implications for cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
There is limited information on body composition, energy balance, and fitness among survivors of childhood acute lymphoblastic leukemia (ALL), especially those treated without cranial radiation therapy (CRT). This analysis compares these metrics among 365 ALL survivors with a mean age of 28.6 ± 5.9 years (149 treated with and 216 without CRT) and 365 age-, sex-, and race-matched peers. We also report risk factors for outcomes among survivors treated without CRT. Male survivors not exposed to CRT had abnormal body composition when compared with peers (% body fat, 26.2 ± 8.2 vs 22.7 ± 7.1). Survivors without CRT had similar energy balance but had significantly impaired quadriceps strength (-21.9 ± 6.0 Newton-meters [Nm]/kg, 60°/s) and endurance (-11.4 ± 4.6 Nm/kg, 300°/s), exercise capacity (-2.0 ± 2.1 ml/kg per minute), low-back and hamstring flexibility (-4.7 ± 1.6 cm), and dorsiflexion range of motion (-3.1 ± 0.9°) and higher modified total neuropathy scores (+1.6 ± 1.1) than peers. Cumulative asparaginase dose ≥120,000 IU/m(2) was associated with impaired flexibility, vincristine dose ≥39 mg/m(2) with peripheral neuropathy, glucocorticoid (prednisone equivalent) dose ≥8000 mg/m(2) with hand weakness, and intrathecal methotrexate dose ≥225 mg with dorsiflexion weakness. Physical inactivity was associated with hand weakness and decreased exercise capacity. Smoking was associated with peripheral neuropathy. Elimination of CRT from ALL therapy has improved, but not eliminated, body-composition outcomes. Survivors remain at risk for impaired fitness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.