ArticleCerebral cortex (New York, N.Y. : 1991)2016
Impaired Organization of Paired-Pulse TMS-Induced I-Waves After Human Spinal Cord Injury.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04807764 (Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury), which is not on this map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury
Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- Multisite Hebbian Plasticity Restores Function in Humans with Spinal Cord Injury.Annals of neurology · 2023Trial
- Synaptic control of retinal ganglion cell survival and axon regeneration.Molecular neurodegeneration · 2026Review
- Article
- Intracortical facilitation and inhibition in human primary motor cortex during motor skill acquisition.Experimental brain research · 2022Article
- Altered regulation of Ia afferent input during voluntary contraction in humans with spinal cord injury.eLife · 2022Article
- Impaired phase synchronization of motor-evoked potentials reflects the degree of motor dysfunction in the lesioned human brain.Human brain mapping · 2022Article
- Spinal Cord Injury and Loss of Cortical Inhibition.International journal of molecular sciences · 2022Review
- Cerebellar transcranial direct current stimulation disrupts neuroplasticity of intracortical motor circuits.PloS one · 2022Article
- Utility of transcranial magnetic stimulation in the assessment of spinal cord injury: Current status and future directions.Frontiers in rehabilitation sciences · 2022Review
- Paired pulse transcranial magnetic stimulation in the assessment of biceps voluntary activation in individuals with tetraplegia.Frontiers in human neuroscience · 2022Article
- Abnormal changes in motor cortical maps in humans with spinal cord injury.The Journal of physiology · 2021Article
- Distinct patterns of spasticity and corticospinal connectivity following complete spinal cord injury.The Journal of physiology · 2021Article
- Evidence for Subcortical Plasticity after Paired Stimulation from a Wearable Device.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Good test-retest reliability of a paired-pulse transcranial magnetic stimulation protocol to measure short-interval intracortical facilitation.Experimental brain research · 2020Article
- Transcranial magnetic stimulation: a non-invasive window into the excitatory circuits involved in human motor behavior.Experimental brain research · 2020Review
- Muscle-specific modulation of indirect inputs to primary motor cortex during action observation.Experimental brain research · 2020Article
- Characterising the influence of cerebellum on the neuroplastic modulation of intracortical motor circuits.PloS one · 2020Article
- Time-Frequency Representation of Motor Evoked Potentials in Brain Tumor Patients.Frontiers in neurology · 2020Article
- Statistical Inter-stimulus Interval Window Estimation for Transient Neuromodulation via Paired Mechanical and Brain Stimulation.Frontiers in neurorobotics · 2020Article
- Changes in motor-evoked potential latency during grasping after tetraplegia.Journal of neurophysiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Paired-pulse transcranial magnetic stimulation (TMS) of the human motor cortex results in consecutive facilitatory motor-evoked potential (MEP) peaks in surface electromyography in intact humans. Here, we tested the effect of an incomplete cervical spinal cord injury (SCI) on early (first) and late (second and third) MEP peaks in a resting intrinsic finger muscle. We found that all peaks had decreased amplitude in SCI subjects compared with controls. The second and third peaks were delayed with the third peak also showing an increased duration. The delay of the third peak was smaller than that seen in controls at lower stimulation intensity, suggesting lesser influence of decreased corticospinal inputs. A mathematical model showed that after SCI the third peak aberrantly contributed to spinal motoneurone recruitment, regardless on the motor unit threshold tested. Temporal and spatial aspects of the late peaks correlated with MEP size and hand motor output. Thus, early and late TMS-induced MEP peaks undergo distinct modulation after SCI, with the third peak likely reflecting a decreased ability to summate descending volleys at the spinal level. We argue that the later corticospinal inputs on the spinal cord might be crucial for recruitment of motoneurones after human SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.