Observational studyJournal of the American Society of Nephrology : JASN2015
A Lifetime of Allograft Function with Kidneys from Older Donors.
Observational study in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Single Versus Dual Kidney Transplants From Marginal Donors: Balancing Survival and Resource Utilization.Journal of transplantation · 2025Article
- Perceptions of Palliative Care Among Patients With Kidney Allograft Dysfunction: A Qualitative Study.Kidney medicine · 2024Article
- Kidney transplants from elderly donors: what we have learned 20 years after the Crystal City consensus criteria meeting.Journal of nephrology · 2024Review
- Transplant Nephrectomy: A Comparative Study of Timing and Techniques in a Single Institution.Annals of transplantation · 2024Article
- [Kidney transplantation].Chirurgie (Heidelberg, Germany) · 2024Review
- Disparities in Deceased Donor Kidney Offer Acceptance: A Survey of Canadian Transplant Nephrologists, General Surgeons and Urologists.Canadian journal of kidney health and disease · 2023Article
- Rationale for Surrogate Endpoints and Conditional Marketing Authorization of New Therapies for Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2022Review
- Transplanting kidneys from donors with small renal masses - a strategy to expand the donor pool.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2020Review
- Article
- Association Between Declined Offers of Deceased Donor Kidney Allograft and Outcomes in Kidney Transplant Candidates.JAMA network open · 2019Article
- Renal transplants from older deceased donors: Is pre-implantation biopsy useful? A monocentric observational clinical study.World journal of transplantation · 2018Article
- Renal Transplants from Older Deceased Donors: Use of Preimplantation Biopsy and Differential Allocation to Dual or Single Kidney Transplant according to Histological Score Has No Advantages over Allocation to Single Kidney Transplant by Simple Clinical Indication.Journal of transplantation · 2018Article
- GFR Evaluation in Living Kidney Donor Candidates.Journal of the American Society of Nephrology : JASN · 2017Article
- Strategies for an Expanded Use of Kidneys From Elderly Donors.Transplantation · 2017Review
- Stretching the Limits of Renal Transplantation in Elderly Recipients of Grafts from Elderly Deceased Donors.Journal of the American Society of Nephrology : JASN · 2017Article
- Older candidates for kidney transplantation: Who to refer and what to expect?World journal of transplantation · 2016Review
- Transplantation: The vexing challenges of deceased donor organ allocation.Nature reviews. Nephrology · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strategies to increase expanded criteria donor (ECD) transplantation are needed. We quantified the extent to which ECD kidneys provide recipients with a lifetime of allograft function by determining the difference between patient survival and death-censored allograft survival (graft survival). Initial analyses compared 5-year outcomes in the Eurotransplant Senior Program (European) and the United States Renal Data System. Among European recipients ≥65 years, patient survival exceeded graft survival, and ECD recipients returned to dialysis for an average of 5.2 months after transplant failure. Among United States recipients ≥60 years, graft survival exceeded patient survival. Although patient survival in elderly recipients in the United States was low (49% at 5 years), the average difference in patient survival at 10 years in elderly recipients in the United States with an ECD versus non-ECD transplant was only 7 months. The probability of patient survival with a functioning allograft at 5 years was higher with ECD transplantation within 1 year after activation to the waiting list than with delayed non-ECD transplantation ≥3 years after activation to the waiting list. Subsequent analyses demonstrated that ECD transplants do not provide a lifetime of allograft function in recipients <50 years in the United States. These findings should encourage ECD transplantation in patients ≥60 years, demonstrate that rapid ECD transplantation is superior to delayed non-ECD transplantation, and challenge the policy in the United States of allowing patients <50 years to receive an ECD transplant.
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