Evidence map›Paper›PMID 25814418›Full record

ArticleHeart rhythm2015

Race- and sex-related differences in care for patients newly diagnosed with atrial fibrillation.

Prashant D Bhave, Xin Lu, Saket Girotra, Hooman Kamel, Mary S Vaughan Sarrazin

Abstract read
In one paragraph

Article in Heart rhythm, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Guideline
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  3. Pooled it
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  8. Trends in percutaneous pericardial access during catheter ablation of ventricular arrhythmias: a single-center experience.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2016
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  9. Trial
  10. Review
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  12. A single centre experience of pulsed field ablation for atrial fibrillation using the Medtronic PulseSelect System: an analysis of the first 100 patients.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  13. Article
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  16. Observational
  17. Atrial fibrillation in the Americas.Lancet regional health. Americas · 2025
    Review
  18. Article
  19. Article
  20. Sex- and age-specific differences in the use of antiarrhythmic therapies among atrial fibrillation patients: a nationwide cohort study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Prashant D BhaveUniversity of Iowa Hospitals and Clinics, Iowa City, Iowa. Electronic address: pdbhave@gmail.com.
Xin LuUniversity of Iowa Hospitals and Clinics, Iowa City, Iowa.
Saket GirotraUniversity of Iowa Hospitals and Clinics, Iowa City, Iowa.
Hooman KamelFeil Family Brain and Mind Research Institute, New York, New York; Department of Neurology, Weill Cornell Medical College, New York, New York.
Mary S Vaughan SarrazinUniversity of Iowa Hospitals and Clinics, Iowa City, Iowa; Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Affairs Medical Center, Iowa City, Iowa.

Funding

Atrial Fibrillation Precursors May Be Novel Stroke Risk FactorsK23NS082367 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KAMEL, HOOMAN · 2013 to 2017
$937k
Post-Resuscitation Care and Survival After In-hospital Cardiac ArrestK08HL122527 · NHLBI · UNIVERSITY OF IOWA · PI GIROTRA, SAKET · 2014 to 2018
$731k
Comparative effectiveness of dabigatran and warfarin for stroke prevention in atrK18HS021992 · AHRQ · UNIVERSITY OF IOWA · PI VAUGHAN SARRAZIN, MARY S · 2012 to 2013
$306k
AHRQ HHS 5K18HS021992AHRQ HHS K18 HS021992NHLBI NIH HHS K08 HL122527NINDS NIH HHS K23 NS082367NINDS NIH HHS K23NS082367
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is associated with an increased risk of stroke and death. Uniform utilization of appropriate therapies for AF may help reduce those risks.

objectiveWe sought to determine whether significant race and sex differences exist in the treatment of newly diagnosed AF in Medicare beneficiaries.

methodsWe used administrative encounter data for Medicare beneficiaries to identify patients with newly diagnosed AF during 2010-2011. Services received after initial AF diagnosis were cataloged, including visits with a cardiologist or electrophysiologist, catheter ablation procedures, and use of oral anticoagulants, rate control agents, and antiarrhythmic drugs.

resultsOverall, 517,941 patients met study criteria, of whom 452,986 (87%) were white, 36,425 (7%) black, and 28,530 (6%) Hispanic. Male patients comprised 209,788 (41%) of the cohort. In multivariate analysis, there were statistically significant differences in the use of AF-related services by both race and sex, with white patients and male patients receiving the most care. The most notable disparities were for catheter ablation (Hispanic vs white: adjusted hazard ratio [AHR] 0.70; 95% confidence interval [CI] 0.63-0.79; P < .001; female vs male: AHR 0.65; 95% CI 0.63-0.68; P < .001) and receipt of oral anticoagulation (black vs white: AHR 0.94; 95% CI 0.92-0.95; P < .001; Hispanic vs white: AHR 0.94; 95% CI 0.93-0.97; P < .001; female vs male: AHR 0.93; 95% CI 0.93-0.94; P < .001).

conclusionRace and sex appear to have a significant effect on the health care provided to this cohort of Medicare beneficiaries diagnosed with AF. Possible explanations include racial differences in access, patient preferences, treatment bias, and unmeasured clinical characteristics.

Indexed as

Atrial FibrillationAgedAged, 80 and overAnti-Arrhythmia AgentsAnticoagulantsBlack or African AmericanCatheter AblationFemaleHealthcare DisparitiesHispanic or LatinoHumansMaleMedicareSex FactorsStrokeUnited StatesAnti-Arrhythmia AgentsAnticoagulantsAtrial fibrillationDisparitiesOutcomes

Identifiers

PMID25814418
PMCPMC4787261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.