Evidence map›Paper›PMID 25814189›Full record

ReviewPharmacological research2015

Re-engineering islet cell transplantation.

Nicoletta Fotino, Carmen Fotino, Antonello Pileggi

Abstract readReview
In one paragraph

Review in Pharmacological research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. [Research progress on the donor cell sources of pancreatic islet transplantation for treatment of diabetes mellitus].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018
    Review
  8. Review
  9. Article
  10. Article
  11. Beneficial effects of growth hormone-releasing hormone agonists on rat INS-1 cells and on streptozotocin-induced NOD/SCID mice.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicoletta FotinoCell Transplant Center, Diabetes Research Institute, University of Miami, USA; University of Pisa, Italy.
Carmen FotinoCell Transplant Center, Diabetes Research Institute, University of Miami, USA.
Antonello PileggiCell Transplant Center, Diabetes Research Institute, University of Miami, USA; Departments of Surgery, Miller School of Medicine, University of Miami, USA; Departments of Microbiology and Immunology, Miller School of Medicine, University of Miami, USA; Department of Biomedical Engineering, University of Miami, USA. Electronic address: apileggi@miami.edu.

Funding

Virginia Mason/UCHSC Autoimmune Prevention CenterU19AI050864 · NIAID · UNIVERSITY OF COLORADO DENVER · PI EISENBARTH, GEORGE S · 2001 to 2011
$29.2M
Strategies to Improve Long Term Islet Graft SurvivalU01DK070460 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RICORDI, CAMILLO · 2004 to 2012
$11.6M
ISLET CELL RESOURCE FOR DIABETES RESEARCH AND TREATMENTU42RR016603 · NCRR · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RICORDI, CAMILLO · 2001 to 2009
$7.8M
PATHWAYS TO TOLERANCE IN HUMAN ISLET TRANSPLANTATIONR01DK056953 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RICORDI, CAMILLO · 2000 to 2004
$5.1M
Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell ReplicationU01DK089538 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEWART, ANDREW F. · 2010 to 2014
$3.6M
Insulin Producing Cells from Amniotic Stem Cells for Diabetes TherapyR01EB008009 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ATALA, ANTHONY · 2007 to 2009
$3.3M
STUDY OF COSTIMULATION BLOCKADE FOR THE PREVENTION OF ISLET ALLOGRAFT REJECTIONU19AI043900 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KNECTLE, STUART J · 1998 to 2001
$3.0M
PANCREATIC TRANSPLANTATION AND DIABETIC MELLITUSR01DK025802 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI INVERARDI, LUCA · 1986 to 2005
$2.5M
NOVEL STRATEGIES TO IMPROVE VIABILITY OF ISLETSR01DK059993 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PASTORI, RICARDO L · 2002 to 2009
$1.6M
Novel Chimeric Molecule to Improve Islet transplantationR21DK076098 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PASTORI, RICARDO L · 2006 to 2007
$375k
NCRR NIH HHS 5U42RR016603-08S1NCRR NIH HHS U42 RR016603NIAID NIH HHS 5U19AI050864-10NIAID NIH HHS U19 AI043900NIAID NIH HHS U19 AI050864NIBIB NIH HHS 1R01EB008009-02NIDDK NIH HHS 1U01DK70460-02NIDDK NIH HHS 5R01DK25802-24NIDDK NIH HHS 5R01DK56953-05NIDDK NIH HHS R01 DK025802NIDDK NIH HHS R01 DK056953NIDDK NIH HHS U01 DK070460NIDDK NIH HHS U01 DK089538NIDDK NIH HHS U01DK089538
6 · The paper itself

Abstract

We are living exciting times in the field of beta cell replacement therapies for the treatment of diabetes. While steady progress has been recorded thus far in clinical islet transplantation, novel approaches are needed to make cell-based therapies more reproducible and leading to long-lasting success. The multiple facets of diabetes impose the need for a transdisciplinary approach to attain this goal, by targeting immunity, promoting engraftment and sustained functional potency. We discuss herein the emerging technologies applied to this rapidly evolving field.

Indexed as

AnimalsBioengineeringDiabetes MellitusDiabetes Mellitus, Type 1HumansImmunomodulationIslets of Langerhans TransplantationBeta cellsBiomaterialsCellular therapiesDiabetesImplantable devicesInsulinIslets of LangerhansIslet transplantationStem cellsTissue engineering

Identifiers

PMID25814189
PMCPMC4469528

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.