Evidence map›Paper›PMID 25814054›Full record

Trial reportBreast cancer research and treatment2015

The effect of YOCAS©® yoga for musculoskeletal symptoms among breast cancer survivors on hormonal therapy.

Luke J Peppone, Michelle C Janelsins, Charles Kamen, Supriya G Mohile, Lisa K Sprod, Jennifer S Gewandter, Jeffrey J Kirshner, Rakesh Gaur, Janet Ruzich, Benjamin T Esparaz and 1 more

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Breast cancer research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 42 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 12 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04001751 nacompletednot on this mapstarted 2018, after this paper: background citation

Feasibility Study of the "SKYPE" Educational Project in Patients With Breast Cancer Treated With Hormonotherapy

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2018 to 2019Enrolled24ConditionsBreast CancerArmseducational yoga program
NCT04457895 narecruitingnot on this mapstarted 2021, after this paper: background citation

A Randomized, Open-labelled, Controlled Trial Evaluating the Efficacy of a Physical Therapy-yoga-patient Educational Program for Breast Cancer Patients With Pain Due to Hormonal Therapy Treatment.

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2021 to 2028Enrolled108ConditionsBreast CancerArmseducational yoga program, no intervention
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 12 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Yoga for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  3. The role of exercise for pain management in adults living with and beyond cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  4. Pooled it
  5. Systematic Review for the Medical Applications of Meditation in Randomized Controlled Trials.International journal of environmental research and public health · 2022
    Pooled it
  6. Pooled it
  7. The effect of exercise on aromatase inhibitor-induced musculoskeletal symptoms in breast cancer survivors :a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  8. Pooled it
  9. Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018
    Pooled it
  10. Risk factors of pain in breast cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
    Pooled it
  11. Pooled it
  12. A systematic review of yoga interventions as integrative treatment in breast cancer.Journal of cancer research and clinical oncology · 2016
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Luke J PepponeDepartment of Surgery, University of Rochester, Rochester, NY, USA, Luke_Peppone@urmc.rochester.edu.
Michelle C Janelsins
Charles Kamen
Supriya G Mohile
Lisa K Sprod
Jennifer S Gewandter
Jeffrey J Kirshner
Rakesh Gaur
Janet Ruzich
Benjamin T Esparaz
Karen M Mustian
University of Rochester · USHeartland Cancer Research · USHematology Oncology Associates of Central New York · USUniversity of North Carolina Wilmington · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Cancer Control Research Training Curriculum (R25T)R25CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C, MORROW, GARY R · 2004 to 2018
$6.7M
The University of Rochester Clinical and Translational Science InstituteKL2TR000095 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$1.7M
Exercise Intervention for Lesbian, Gay, Bisexual, and Transgender Cancer SurvivorsK07CA190529 · NCI · UNIVERSITY OF ROCHESTER · PI KAMEN, CHARLES STEWART · 2015 to 2019
$830k
Interventions Targeting Inflammation for Chemotherapy-Related Cognitive ProblemsK07CA168886 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C · 2013 to 2017
$724k
Management of Cancer-Treatment-Induced Bone LossK07CA168911 · NCI · UNIVERSITY OF ROCHESTER · PI PEPPONE, LUKE JOSEPH · 2013 to 2017
$724k
High-dose Vitamin D Supplementation for ADT-induced Side EffectsR21CA175793 · NCI · UNIVERSITY OF ROCHESTER · PI PEPPONE, LUKE JOSEPH · 2014 to 2015
$367k
NCI NIH HHS K07 CA168886NCI NIH HHS K07 CA168911NCI NIH HHS K07 CA190529NCI NIH HHS R21 CA175793NCI NIH HHS R25 CA102618NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

Up to 50% of breast cancer survivors on aromatase inhibitor therapy report musculoskeletal symptoms such as joint and muscle pain, significantly impacting treatment adherence and discontinuation rates. We conducted a secondary data analysis of a nationwide, multi-site, phase II/III randomized, controlled, clinical trial examining the efficacy of yoga for improving musculoskeletal symptoms among breast cancer survivors currently receiving hormone therapy (aromatase inhibitors [AI] or tamoxifen [TAM]). Breast cancer survivors currently receiving AI (N = 95) or TAM (N = 72) with no participation in yoga during the previous 3 months were randomized into 2 arms: (1) standard care monitoring and (2) standard care plus the 4-week yoga intervention (2x/week; 75 min/session) and included in this analysis. The yoga intervention utilized the UR Yoga for Cancer Survivors (YOCAS©(®)) program consisting of breathing exercises, 18 gentle Hatha and restorative yoga postures, and meditation. Musculoskeletal symptoms were assessed pre- and post-intervention. At baseline, AI users reported higher levels of general pain, muscle aches, and total physical discomfort than TAM users (all P ≤ 0.05). Among all breast cancer survivors on hormonal therapy, participants in the yoga group demonstrated greater reductions in musculoskeletal symptoms such as general pain, muscle aches and total physical discomfort from pre- to post-intervention than the control group (all P ≤ 0.05). The severity of musculoskeletal symptoms was higher for AI users compared to TAM users. Among breast cancer survivors on hormone therapy, the brief community-based YOCAS©® intervention significantly reduced general pain, muscle aches, and physical discomfort.

Indexed as

YogaAromatase InhibitorsBreast NeoplasmsClinical Trials as TopicFemaleHumansKarnofsky Performance StatusMiddle AgedMusculoskeletal DiseasesSurvivorsTamoxifenAromatase InhibitorsTamoxifen

Identifiers

PMID25814054
PMCPMC4467273
OpenAlexW2011242432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.