ArticleInternational journal of molecular medicine2015
Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study.
Article in International journal of molecular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- DNA methylation and stroke prognosis: an epigenome-wide association study.Clinical epigenetics · 2024Pooled it
- Evolutionary history of disease-susceptibility loci identified in longitudinal exome-wide association studies.Molecular genetics & genomic medicine · 2019Trial
- Genetic investigations on singleton school aged children reveal novel variants and new candidate genes for hearing loss.Scientific reports · 2024Article
- Genetics of Hypertension: From Monogenic Analysis to GETomics.Journal of cardiovascular development and disease · 2024Review
- Association Between ABCA1 Gene Polymorphisms and the Risk of Hypertension in the Chinese Han Population.Frontiers in public health · 2022Article
- Prevalence of and risk factors for hypertension in Ethiopia: A systematic review and meta-analysis.Health science reports · 2021Review
- Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia.International journal of molecular medicine · 2019Article
- Familial aggregation and heritability of hypertension in Han population in Shanghai China: a case-control study.Clinical hypertension · 2019Article
- Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population.Biomedical reports · 2018Article
- Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease.International journal of molecular medicine · 2018Article
- Identification of nine novel loci related to hematological traits in a Japanese population.Physiological genomics · 2018Article
- Six novel susceptibility loci for coronary artery disease and cerebral infarction identified by longitudinal exome-wide association studies in a Japanese population.Biomedical reports · 2018Article
- Identification of four genes as novel susceptibility loci for early-onset type 2 diabetes mellitus, metabolic syndrome, or hyperuricemia.Biomedical reports · 2018Article
- Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage.Biomedical reports · 2018Article
- Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.Molecular genetics and genomics : MGG · 2018Article
- Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population.Physiological genomics · 2018Article
- Prediction of Disordered Regions and Their Roles in the Anti-Pathogenic and Immunomodulatory Functions of Butyrophilins.Molecules (Basel, Switzerland) · 2018Article
- Longitudinal exome-wide association study to identify genetic susceptibility loci for hypertension in a Japanese population.Experimental & molecular medicine · 2017Article
- Association of smoking with prevalence of common diseases and metabolic abnormalities in community-dwelling Japanese individuals.Biomedical reports · 2017Article
- Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously identified 9 genes and chromosomal region 3q28 as susceptibility loci for Japanese patients with myocardial infarction, ischemic stroke, or chronic kidney disease by genome-wide or candidate gene association studies. In the present study, we investigated the possible association of 13 single nucleotide polymorphisms (SNPs) at these 10 loci with the prevalence of hypertension or their association with blood pressure (BP) in community-dwelling individuals in Japan. The study subjects comprised 6,027 individuals (2,250 subjects with essential hypertension, 3,777 controls) who were recruited into the Inabe Health and Longevity Study, a longitudinal genetic epidemiological study on atherosclerotic, cardiovascular and metabolic diseases. The subjects were recruited from individuals who visited the Health Care Center of Inabe General Hospital for an annual health checkup, and they are followed up each year (mean follow‑up period, 5 years). Longitudinal analysis with a generalized estimating equation and with adjustment for age, gender, body mass index and smoking status revealed that rs2116519 of family with sequence similarity 78, member B (FAM78B; P=0.0266), rs6929846 of butyrophilin, subfamily 2, member A1 (BTN2A1; P=0.0013), rs146021107 of pancreatic and duodenal homeobox 1 (PDX1; P=0.0031) and rs1671021 of lethal giant larvae homolog 2 (Drosophila) (LLGL2; P=0.0372) were significantly (P<0.05) associated with the prevalence of hypertension. Longitudinal analysis with a generalized linear mixed-effect model and with adjustment for age, gender, body mass index and smoking status among individuals not taking anti-hypertensive medication revealed that rs6929846 of BTN2A1 was significantly associated with systolic (P=0.0017), diastolic (P=0.0008) and mean (P=0.0005) BP, and that rs2116519 of FAM78B, rs146021107 of PDX1 and rs1671021 of LLGL2 were significantly associated with diastolic (P=0.0495), systolic (P=0.0132), and both diastolic (P=0.0468) and mean (0.0471) BP, respectively. BTN2A1 may thus be a susceptibility gene for hypertension.
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