Evidence map›Paper›PMID 25813399›Full record

ArticleNature communications2015

Global migration of influenza A viruses in swine.

Martha I Nelson, Cécile Viboud, Amy L Vincent, Marie R Culhane, Susan E Detmer, David E Wentworth, Andrew Rambaut, Marc A Suchard, Edward C Holmes, Philippe Lemey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Influenza.Nature reviews. Disease primers · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martha I NelsonDivision of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
Cécile ViboudDivision of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
Amy L VincentVirus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-ARS, Ames, Iowa 50010, USA.
Marie R CulhaneUniversity of Minnesota Veterinary Diagnostic Laboratory, St Paul, Minnesota 55108, USA.
Susan E DetmerWestern College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A8, Canada.
David E WentworthJ Craig Venter Institute, Rockville, Maryland 20850, USA.
Andrew Rambaut1] Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA [2] Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 FLT, UK [3] Centre for Immunology, Infection and Evolution, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 FLT, UK.
Marc A SuchardDepartments of Biomathematics, Biostatistics, and Human Genetics, University of California, Los Angeles, California 90095, USA.
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, University of Sydney, Sydney New South Wales 2006, Australia.
Philippe LemeyDepartment of Microbiology and Immunology, Rega Institute, KU Leuven-University of Leuven, Leuven, Belgium.

Funding

European Research Council 260864Intramural NIH HHS Z99 TW999999NIAID NIH HHS HHSN272200900007CWellcome Trust 095831
6 · The paper itself

Abstract

The complex and unresolved evolutionary origins of the 2009 H1N1 influenza pandemic exposed major gaps in our knowledge of the global spatial ecology and evolution of influenza A viruses in swine (swIAVs). Here we undertake an expansive phylogenetic analysis of swIAV sequence data and demonstrate that the global live swine trade strongly predicts the spatial dissemination of swIAVs, with Europe and North America acting as sources of viruses in Asian countries. In contrast, China has the world's largest swine population but is not a major exporter of live swine, and is not an important source of swIAVs in neighbouring Asian countries or globally. A meta-population simulation model incorporating trade data predicts that the global ecology of swIAVs is more complex than previously thought, and the United States and China's large swine populations are unlikely to be representative of swIAV diversity in their respective geographic regions, requiring independent surveillance efforts throughout Latin America and Asia.

Indexed as

AnimalsAsiaBase SequenceCanadaChinaCommerceEuropeInfluenza A virusInternationalityLatin AmericaMexicoMolecular EpidemiologyMolecular Sequence DataNorth AmericaOrthomyxoviridae InfectionsRNA, ViralRNA, Viral

Identifiers

PMID25813399
PMCPMC4380236

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.