Evidence map›Paper›PMID 25813213›Full record

ReviewCurrent atherosclerosis reports2015

Fibroblast growth factor signaling in the vasculature.

Xuehui Yang, Lucy Liaw, Igor Prudovsky, Peter C Brooks, Calvin Vary, Leif Oxburgh, Robert Friesel

Open access · greenAbstract readReview
In one paragraph

Review in Current atherosclerosis reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 109 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Article
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  6. Article
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  8. Article
  9. Endothelial to mesenchymal transition: a central mechanism in diabetes-induced vascular pathology.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. FGF1 as a New Promising Therapeutic Target in Type 2 Diabetes: Advances in Research and Clinical Trials.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  17. Bioengineering vascularization.Development (Cambridge, England) · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xuehui YangCenter for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA.
Lucy Liaw
Igor Prudovsky
Peter C Brooks
Calvin Vary
Leif Oxburgh
Robert Friesel
Maine Medical Center Research Institute · USMaine Medical Center · US

Funding

Phase III COBRE in Vascular BiologyP30GM103392 · NIGMS · MAINEHEALTH · PI ST. GERMAIN, DONALD L. · 2012 to 2016
$4.7M
Defining the progenitor cell niche of the developing kidneyR01DK078161 · NIDDK · MAINEHEALTH · PI OXBURGH, LEIF · 2008 to 2016
$3.4M
Smooth muscle cell integration of differentiation signalsR01HL109652 · NHLBI · MAINEHEALTH · PI LIAW, LUCY · 2012 to 2015
$1.5M
NHLBI NIH HHS R01 HL109652NIDDK NIH HHS R01 DK078161NIGMS NIH HHS P30 GM103392
6 · The paper itself

Abstract

Despite their discovery as angiogenic factors and mitogens for endothelial cells more than 30 years ago, much remains to be determined about the role of fibroblast growth factors (FGFs) and their receptors in vascular development, homeostasis, and disease. In vitro studies show that members of the FGF family stimulate growth, migration, and sprouting of endothelial cells, and growth, migration, and phenotypic plasticity of vascular smooth muscle cells. Recent studies have revealed important roles for FGFs and their receptors in the regulation of endothelial cell sprouting and vascular homeostasis in vivo. Furthermore, recent work has revealed roles for FGFs in atherosclerosis, vascular calcification, and vascular dysfunction. The large number of FGFs and their receptors expressed in endothelial and vascular smooth muscle cells complicates these studies. In this review, we summarize recent studies in which new and unanticipated roles for FGFs and their receptors in the vasculature have been revealed.

Indexed as

AnimalsBlood VesselsEndothelial CellsFibroblast Growth FactorsHumansMuscle, Smooth, VascularMyocytes, Smooth MuscleSignal TransductionFibroblast Growth Factors

Identifiers

PMID25813213
PMCPMC4593313
OpenAlexW2027472172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.