ArticleBioorganic & medicinal chemistry letters2015
Small cyclic agonists of iron regulatory hormone hepcidin.
Article in Bioorganic & medicinal chemistry letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The macrocycle inhibitor landscape of SLC-transporter.Molecular informatics · 2024Article
- A randomized placebo-controlled clinical trial of oral green tea epigallocatechin 3-gallate on erythropoiesis and oxidative stress in transfusion-dependent β-thalassemia patients.Frontiers in molecular biosciences · 2023Article
- Structural basis of ferroportin inhibition by minihepcidin PR73.PLoS biology · 2023Article
- Iron Therapeutics in Women's Health: Past, Present, and Future.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Therapeutic Advances in Regulating the Hepcidin/Ferroportin Axis.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Position of lipidation influences anticancer activity of Smac analogs.Bioorganic & medicinal chemistry letters · 2019Article
- A Targeted Mass Spectrometric Assay for Reliable Sensitive Hepcidin Quantification.Scientific reports · 2019Article
- Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux.The Journal of biological chemistry · 2019Article
- Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects.Mediators of inflammation · 2019Article
- Hepcidin Therapeutics.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Cyclization of peptides with two chemical bridges affords large scaffold diversities.Nature chemistry · 2018Article
- The C19S Substitution Enhances the Stability of Hepcidin While Conserving Its Biological Activity.The protein journal · 2018Article
- Current understanding of iron homeostasis.The American journal of clinical nutrition · 2017Review
- Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation.International journal of peptide research and therapeutics · 2016Article
- Pharmacological Targeting of the Hepcidin/Ferroportin Axis.Frontiers in pharmacology · 2016Review
- Lipid-conjugated Smac analogues.Bioorganic & medicinal chemistry letters · 2015Article
- Retinal abnormalities in β-thalassemia major.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Minihepcidins are in vitro and in vivo active mimetics of iron-regulatory hormone hepcidin. They contain various unusual amino acids including: N-substituted, β-homo-, and d-amino acids with their combination depending on particular minihepcidin. In the current study, we sought to limit the use of unusual/more expensive amino acids derivatives by peptide cyclization. Novel cyclic mimetics of hepcidin were synthesized and tested in vitro and showed activity at low nanomolar concentration. Nonetheless, the most active cyclic compound (mHS17) is approximately ten times less active than the parental minihepcidin PR73. Collectively, our findings suggest that cyclization is viable approach in the synthesis of hepcidin mimetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.