ArticleNucleic acids research2015
Post-conversion targeted capture of modified cytosines in mammalian and plant genomes.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Epigenetics in forest trees- key driver to phenotypic plasticity and adaptation under stress.Functional & integrative genomics · 2025Review
- Population epigenetics: DNA methylation in the plant omics era.Plant physiology · 2024Article
- Exploring the crop epigenome: a comparison of DNA methylation profiling techniques.Frontiers in plant science · 2023Review
- Target-enriched enzymatic methyl sequencing: Flexible, scalable and inexpensive hybridization capture for quantifying DNA methylation.PloS one · 2023Article
- Article
- Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns.Advances in experimental medicine and biology · 2022Article
- A novel statistical method for modeling covariate effects in bisulfite sequencing derived measures of DNA methylation.Biometrics · 2021Article
- High-resolution targeted bisulfite sequencing reveals blood cell type-specific DNA methylation patterns in IL13 and ORMDL3.Clinical epigenetics · 2021Observational
- Methylated biomarkers for breast cancer identified through public database analysis and plasma target capture sequencing.Annals of translational medicine · 2021Article
- Targeted bisulfite sequencing for biomarker discovery.Methods (San Diego, Calif.) · 2021Article
- Epigenetic Regulation of ABA-Induced Transcriptional Responses in Maize.G3 (Bethesda, Md.) · 2020Article
- Latest techniques to study DNA methylation.Essays in biochemistry · 2019Review
- Population-level analysis reveals the widespread occurrence and phenotypic consequence of DNA methylation variation not tagged by genetic variation in maize.Genome biology · 2019Article
- Global DNA Methylation Patterns in Human Gliomas and Their Interplay with Other Epigenetic Modifications.International journal of molecular sciences · 2019Review
- Sequencing in High Definition Drives a Changing Worldview of the Epigenome.Cold Spring Harbor perspectives in medicine · 2019Review
- Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism.International journal of epidemiology · 2018Review
- Detection of somatic epigenetic variation in Norway spruce via targeted bisulfite sequencing.Ecology and evolution · 2018Article
- Whole-genome bisulfite sequencing with improved accuracy and cost.Genome research · 2018Article
- Article
- "Same difference": comprehensive evaluation of four DNA methylation measurement platforms.Epigenetics & chromatin · 2018Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a capture-based approach for bisulfite-converted DNA that allows interrogation of pre-defined genomic locations, allowing quantitative and qualitative assessments of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) at CG dinucleotides and in non-CG contexts (CHG, CHH) in mammalian and plant genomes. We show the technique works robustly and reproducibly using as little as 500 ng of starting DNA, with results correlating well with whole genome bisulfite sequencing data, and demonstrate that human DNA can be tested in samples contaminated with microbial DNA. This targeting approach will allow cell type-specific designs to maximize the value of 5mC and 5hmC sequencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.