ArticleVaccine2015
Deaths averted by influenza vaccination in the U.S. during the seasons 2005/06 through 2013/14.
Article in Vaccine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Decade in Review: A Systematic Review of Universal Influenza Vaccines in Clinical Trials during the 2010 Decade.Viruses · 2020Pooled it
- Heterogeneity in Estimates of the Impact of Influenza on Population Mortality: A Systematic Review.American journal of epidemiology · 2018Pooled it
- Motivational Interviewing for Vaccine Uptake in Latinx Adults (MI Vacuna): Study protocol for a pragmatic multiple-period cluster-randomized crossover trial.Contemporary clinical trials · 2025Article
- Influenza: temporal trends in mortality, hospitalization, and vaccination in the older adults population aged 60 and more years, Brazil, 2000-2023.Frontiers in public health · 2025Article
- Direct impact of COVID-19 vaccination in Chile: averted cases, hospitalizations, ICU admissions, and deaths.BMC infectious diseases · 2024Article
- Analysis of risk factors for hospital-acquired pneumonia in schizophrenia.Frontiers in psychiatry · 2024Review
- Article
- Coverage and impact of influenza vaccination among children in Minhang District, China, 2013-2020.Frontiers in public health · 2023Article
- Article
- Fabrication of microneedle patches with lyophilized influenza vaccine suspended in organic solvent.Drug delivery and translational research · 2021Article
- Review
- Subtypes of Influenza Virus Infection and Outcomes in Individuals Older than 65 Years of Age in Poland in the 2016/2017 to 2019/2020 Epidemic Seasons.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Influencing Factors of Hospital-Acquired Pneumonia Infection in the Middle-Aged and Elderly Patients With Schizophrenia.Frontiers in psychiatry · 2021Article
- Reducing the infectious diseases burden through "life course approach vaccination" in India-a perspective.AIMS public health · 2021Article
- The Second Wave of COVID-19 Pandemic Strikes during the Flu Season: An Awareness Perspective.Medicina (Kaunas, Lithuania) · 2020Article
- State-level estimates of excess hospitalizations and deaths associated with influenza.Influenza and other respiratory viruses · 2020Article
- Brand-Specific Enhanced Safety Surveillance of GSK's Quadrivalent Seasonal Influenza Vaccine in Belgium, Germany and Spain for the 2018/2019 Season.Drug safety · 2020Article
- Impact of national influenza vaccination strategy in severe influenza outcomes among the high-risk Portuguese population.BMC public health · 2019Article
- Impact of influenza vaccination programmes among the elderly population on primary care, Portugal, Spain and the Netherlands: 2015/16 to 2017/18 influenza seasons.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Challenges in estimating influenza vaccine effectiveness.Expert review of vaccines · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundExcess mortality due to seasonal influenza is substantial, yet quantitative estimates of the benefit of annual vaccination programs on influenza-associated mortality are lacking.
methodsWe estimated the numbers of deaths averted by vaccination in four age groups (0.5 to 4, 5 to 19, 20 to 64 and ≥65 yrs.) for the nine influenza seasons from 2005/6 through 2013/14. These estimates were obtained using a Monte Carlo approach applied to weekly U.S. age group-specific estimates of influenza-associated excess mortality, monthly vaccination coverage estimates and summary seasonal influenza vaccine effectiveness estimates to obtain estimates of the number of deaths averted by vaccination. The estimates are conservative as they do not include indirect vaccination effects.
resultsFrom August, 2005 through June, 2014, we estimated that 40,127 (95% confidence interval [CI] 25,694 to 59,210) deaths were averted by influenza vaccination. We found that of all studied seasons the most deaths were averted by influenza vaccination during the 2012/13 season (9398; 95% CI 2,386 to 19,897) and the fewest during the 2009/10 pandemic (222; 95% CI 79 to 347). Of all influenza-associated deaths averted, 88.9% (95% CI 83 to 92.5%) were in people ≥65 yrs. old.
conclusionsThe estimated number of deaths averted by the US annual influenza vaccination program is considerable, especially among elderly adults and even when vaccine effectiveness is modest, such as in the 2012/13 season. As indirect effects ("herd immunity") of vaccination are ignored, these estimates represent lower bound estimates and are thus conservative given valid excess mortality estimates.
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