ArticleMolecular imaging2015
Near-infrared fluorescent digital pathology for the automation of disease diagnosis and biomarker assessment.
Article in Molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Histological Hyperspectral Glioblastoma Dataset (HistologyHSI-GB).Scientific data · 2024Article
- Doubly Strapped Zwitterionic NIR-I and NIR-II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging.Angewandte Chemie (International ed. in English) · 2023Article
- Rapid digital pathology of H&E-stained fresh human brain specimens as an alternative to frozen biopsy.Communications medicine · 2023Article
- Hematoxylin Nuclear Stain Reports Oxidative Stress via Near-Infrared Emission.ACS chemical biology · 2023Article
- Generative adversarial network based digital stain conversion for generating RGB EVG stained image from hyperspectral H&E stained image.Journal of biomedical optics · 2023Article
- Automatic detection of head and neck squamous cell carcinoma on histologic slides using hyperspectral microscopic imaging.Journal of biomedical optics · 2022Article
- Evaluation of Cytologic Sample Preparations for Compatibility With Nucleic Acid Analysis.American journal of clinical pathology · 2022Article
- Maintaining of the Green Fluorescence Emission of 9-Aminoanthracene for Bioimaging Applications.ACS omega · 2017Article
- Superresolution Imaging of Clinical Formalin Fixed Paraffin Embedded Breast Cancer with Single Molecule Localization Microscopy.Scientific reports · 2017Article
- An automatic whole-slide hyperspectral imaging microscope.Proceedings of SPIE--the International Society for Optical EngineeringArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Hematoxylin-eosin (H&E) staining of tissue has been the mainstay of pathology for more than a century. However, the learning curve for H&E tissue interpretation is long, whereas intra- and interobserver variability remain high. Computer-assisted image analysis of H&E sections holds promise for increased throughput and decreased variability but has yet to demonstrate significant improvement in diagnostic accuracy. Addition of biomarkers to H&E staining can improve diagnostic accuracy; however, coregistration of immunohistochemical staining with H&E is problematic as immunostaining is completed on slides that are at best 4 μm apart. Simultaneous H&E and immunostaining would alleviate coregistration problems; however, current opaque pigments used for immunostaining obscure H&E. In this study, we demonstrate that diagnostic information provided by two or more independent wavelengths of near-infrared (NIR) fluorescence leave the H&E stain unchanged while enabling computer-assisted diagnosis and assessment of human disease. Using prostate cancer as a model system, we introduce NIR digital pathology and demonstrate its utility along the spectrum from prostate biopsy to whole mount analysis of H&E-stained tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.