ArticleBMC infectious diseases2015
Viral etiology of community-acquired pneumonia among adolescents and adults with mild or moderate severity and its relation to age and severity.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Hospital utilization rates for influenza and RSV: a novel approach and critical assessment.Population health metrics · 2021Pooled it
- The burden of respiratory syncytial virus in adults: a systematic review and meta-analysis.Epidemiology and infection · 2020Pooled it
- Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Pooled it
- Viral infection in community-acquired pneumonia: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2016Pooled it
- Diagnostic Performance and Cost-Effectiveness of BALF mNGS in Older Adults with Pulmonary Infections.Infectious diseases and therapy · 2026Article
- A Machine Learning Approach to Differentiate Cold and Hot Syndrome in Viral Pneumonia Integrating Traditional Chinese Medicine and Modern Medicine: Machine Learning Model Development and Validation.JMIR medical informatics · 2025Article
- Viral non-SARS-CoV-2 etiology of community-acquired pneumonia (CAP) in Southeast Asia: a review and pooled analysis.IJID regions · 2025Review
- Virus profiling of bronchoalveolar lavage fluid in hospitalized non-COVID-19 adult patients with pulmonary infection from November 2020 to November 2021.Virologica Sinica · 2025Article
- Clinical application of metagenomic next-generation sequencing in etiologic diagnosis of severe pneumonia in adults.Frontiers in cellular and infection microbiology · 2025Article
- Can Some Viral Respiratory Infections Observed Before the Pandemic Announcement Be Related to SARS-CoV-2?Thoracic research and practice · 2023Article
- Efficacy and safety of Lianhua Qingwen granule in the treatment of non-influenza viral pneumonia: a randomized, double-blind, placebo-controlled, multicenter clinical study.Frontiers in medicine · 2023Article
- Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China.Emerging microbes & infections · 2022Article
- Current status of human adenovirus infection in China.World journal of pediatrics : WJP · 2022Review
- Comparison of Pneumonia Severity Indices, qCSI, 4C-Mortality Score and qSOFA in Predicting Mortality in Hospitalized Patients with COVID-19 Pneumonia.Journal of personalized medicine · 2022Article
- Clinical and etiological analysis of co-infections and secondary infections in COVID-19 patients: An observational study.The clinical respiratory journal · 2021Observational
- Viral community acquired pneumonia at the emergency department: Report from the pre COVID-19 age.Journal of medical virology · 2021Observational
- Radiological, epidemiological and clinical patterns of pulmonary viral infections.European journal of radiology · 2021Review
- Comparison of COVID-19 and influenza characteristics.Journal of Zhejiang University. Science. B · 2021Review
- Analysis of antibiotic usage for viral community-acquired pneumonia in adults.Frontiers of medicine · 2021Article
- Lower respiratory tract infection in the community: associations between viral aetiology and illness course.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBetter knowledge of distribution of respiratory viruses (RVs) in adolescents and adults with community-acquired pneumonia (CAP) is needed.
methodsTo investigate the RVs etiology among adolescents and adults with CAP, according to age and pneumonia severity index (PSI), a multi-center, prospective study was conducted from November 2010 to April 2012. Fifteen RVs were tested by polymerase chain reaction (PCR). Bacteria were detected by urinary antigen, conventional culture and PCR.
resultsMean (SD) age and median (IQR) PSI score of 954 patients enrolled was 45.2 (19.5) years (range 14-94) and 42 (36). RVs were found in 262 patients (27.5%): influenza virus A (IFV A, 9.9%) comprised of pandemic H1N1 (6.7%) and seasonal H3N2 (3.5%), human rhinovirus (4.3%), adenovirus (4.2%), human metapneumovirus (1.8%), parainfluenza virus 1, 3 and 2 (1.7%, 1.5% and 1.2%). Influenza virus B, enterovirus, respiratory syncytial virus, human coronavirus and parainfluenza virus 4 were rarely detected (<1%). Frequency of IFV A was highest among patients aged between 45-64 years (p < 0.001), while adenovirus among patients aged 14-17 years (p < 0.001), no differences was found in other RVs. The proportion of pandemic H1N1 increased with severity of pneumonia evaluated by PSI (P < 0.05).
conclusionsThe proportion of RVs in CAP is higher than previously reported. IFV A pneumonia are usually found in patients older than 45 years, while, adenovirus pneumonia are common in adolescents and young adults. Pandemic H1N1 virus is still recognized by PSI as a high-severity pathogen. The findings contribute baseline data on viral CAP study in China.
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