ArticleJournal of burn care & research : official publication of the American Burn Association
Oxalate Nephropathy After Continuous Infusion of High-Dose Vitamin C as an Adjunct to Burn Resuscitation.
Article in Journal of burn care & research : official publication of the American Burn Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04153487 (Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Review
- Histological efficacy of high-dose intravenous vitamin C infusion in severely burned patients.Journal of molecular histology · 2025Article
- Intravenous Ascorbic Acid for the Prevention of Postreperfusion Syndrome in Orthotopic Liver Transplantation: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- Vitamins as regulators of calcium-containing kidney stones - new perspectives on the role of the gut microbiome.Nature reviews. Urology · 2023Review
- High-dose intravenous versus low-dose oral vitamin C in burn care: potential protective effects in the severely burned: a retrospective cohort study.Annals of medicine and surgery (2012) · 2023Article
- Oxalate nephropathy: a review.Clinical kidney journal · 2022Article
- High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality.BMC nephrology · 2021Observational
- Any Role of High-Dose Vitamin C for Septic Shock in 2021?Seminars in respiratory and critical care medicine · 2021Article
- Rifle Criteria For Acute Kidney Injury In Burn Patients: Prevalence And Risk Factors.Annals of burns and fire disasters · 2021Article
- Vitamin C reduces vancomycin-related nephrotoxicity through the inhibition of oxidative stress, apoptosis, and inflammation in mice.Annals of translational medicine · 2021Article
- Vitamin C-Induced Oxalate Nephropathy in a Septic Patient.Critical care explorations · 2021Article
- Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection.Journal of global antimicrobial resistance · 2020Review
- Metabolic Resuscitation Using Hydrocortisone, Ascorbic Acid, and Thiamine: Do Individual Components Influence Reversal of Shock Independently?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial.BMJ open · 2020Article
- Burn injury.Nature reviews. Disease primers · 2020Review
- High-Dose Intravenous Ascorbic Acid: Ready for Prime Time in Traumatic Brain Injury?Neurocritical care · 2020Article
- Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in Patients With Colon Cancer: A Clinical Intervention Study.Frontiers in oncology · 2020Article
- Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis.Journal of intensive care · 2020Article
- A Critical Update of the Assessment and Acute Management of Patients with Severe Burns.Advances in wound care · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluid resuscitation is the foundation of management in burn patients and is the topic of considerable research. One adjunct in burn resuscitation is continuous, high-dose vitamin C (ascorbic acid) infusion, which may reduce fluid requirements and thus decrease the risk for over resuscitation. Research in preclinical studies and clinical trials has shown continuous infusions of high-dose vitamin C to be beneficial with decrease in resuscitative volumes and limited adverse effects. However, high-dose and low-dose vitamin C supplementation has been shown to cause secondary calcium oxalate nephropathy, worsen acute kidney injury, and delay renal recovery in non-burn patients. To the best of our knowledge, the authors present the first case series in burn patients in whom calcium oxalate nephropathy has been identified after high-dose vitamin C therapy.
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