Evidence map›Paper›PMID 25811837›Full record

ArticlePloS one2015

Chronic obstructive pulmonary disease and subsequent overall and lung cancer mortality in low-income adults.

Melinda C Aldrich, Heather M Munro, Michael Mumma, Eric L Grogan, Pierre P Massion, Timothy S Blackwell, William J Blot

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Lung Cancer Risk in US Adults with COPD: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Pack-Year Smoking History: An Inadequate and Biased Measure to Determine Lung Cancer Screening Eligibility.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  7. Spatio-Temporal Variation of Lung Cancer in Crete, 1992-2013. Economic or Health Crisis?International journal of environmental research and public health · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. COPD Overlap Syndromes: Asthma and Beyond.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2016
    Article
  12. Article
  13. Defining and targeting health disparities in chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Melinda C AldrichDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, United States of America; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America.
Heather M MunroInternational Epidemiology Institute, Rockville, MD, United States of America.
Michael MummaInternational Epidemiology Institute, Rockville, MD, United States of America.
Eric L GroganDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, United States of America; Tennessee Valley Health System Veterans Affairs, Nashville, TN, United States of America.
Pierre P MassionDivision of Pulmonary and Critical Care Medicine, Thoracic Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United States of America.
Timothy S BlackwellDepartments of Medicine, Cell and Development Biology, and Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, United States of America.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America; International Epidemiology Institute, Rockville, MD, United States of America.
International Epidemiology Institute · USVanderbilt University Medical Center · USVA Tennessee Valley Healthcare System · US

Funding

Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
Unraveling Genetic Determinants of Lung Cancer Risk in African AmericansK07CA172294 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALDRICH, MELINDA · 2013 to 2017
$801k
Decreasing Unnecessary Invasive Lung Cancer Diagnostic ProceduresIK2HX000758 · VA · VETERANS HEALTH ADMINISTRATION · PI GROGAN, ERIC L · 2014 to 2015
–
HSRD VA IK2 HX000758NCI NIH HHS K07 CA172294NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA092447-08S1
6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is a known risk factor for lung cancer and a leading cause of mortality in the U.S., but its impact may not be fully appreciated, especially among low-income populations in the southeast where COPD prevalence and lung cancer incidence are elevated.

methodsWe conducted a prospective study among 26,927 low-income adults age 40-79 in the Southern Community Cohort Study who had a Center for Medicare and Medicaid Services (CMS) encounter prior to enrollment and were followed for a median of over 6 years. Using a validated algorithm for assessing COPD from CMS claims data, we estimated COPD prevalence and potential misreporting. From Cox proportional hazard models, we computed overall and lung cancer-specific mortality according to COPD status.

resultsThe overall prevalence of CMS-diagnosed COPD was 16%, but was twice as high among whites as blacks. Only 35% of these individuals, however, self-reported having COPD, with underreporting significantly greater for blacks than whites. Smoking-adjusted all-cause mortality was increased by 1.7-fold and lung cancer mortality by 2.3-fold among those with a CMS COPD diagnosis, with similar patterns in blacks and whites, but no excess was found among those self-reporting COPD and without CMS confirmation.

conclusionThe prevalence of COPD in this low-income population may be greater than previously recognized and misreporting is common. COPD is associated with elevated lung cancer mortality, even among those not self-reporting the condition.

Indexed as

AdultAgedBlack or African AmericanBlack PeopleCohort StudiesFemaleHumansLung NeoplasmsMaleMiddle AgedMultivariate AnalysisPovertyProportional Hazards ModelsPulmonary Disease, Chronic ObstructiveRisk FactorsUnited States

Identifiers

PMID25811837
PMCPMC4374870
OpenAlexW1982158391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.