SynthesisPloS one2015
Modulation of genetic associations with serum urate levels by body-mass-index in humans.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
102.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1,233 citations in OpenAlex.
- ABCG2 transporter: Structural and functional associations with gout (Review).International journal of molecular medicine · 2026Review
- Selection signature analysis in chickens divergently selected for growth rate reveals novel candidate genes regulating fat deposition.BMC genomics · 2025Article
- Assessing the effect of modifiable risk factors on hepatocellular carcinoma: evidence from a bidirectional Mendelian randomization analysis.Discover oncology · 2025Article
- Association of rare and common genetic variants in MOCOS with inadequate response to allopurinol.Rheumatology (Oxford, England) · 2024Article
- The Causal Effect of Urate Level on Female Infertility: A Mendelian Randomization Study.Metabolites · 2024Article
- A Genome-Wide Association Study of Oxypurinol Concentrations in Patients Treated with Allopurinol.Journal of personalized medicine · 2024Article
- Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.Cell genomics · 2022Article
- Impact of adiposity on risk of female gout among those genetically predisposed: sex-specific prospective cohort study findings over >32 years.Annals of the rheumatic diseases · 2022Article
- Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study.Nutrients · 2022Article
- Association ofFrontiers in genetics · 2021Article
- Automated feature extraction from population wearable device data identified novel loci associated with sleep and circadian rhythms.PLoS genetics · 2020Article
- Multifaceted genome-wide study identifies novel regulatory loci in SLC22A11 and ZNF45 for body mass index in Indians.Molecular genetics and genomics : MGG · 2020Article
- ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.BMC medical genetics · 2020Article
- Identification of genetic heterogeneity of Alzheimer's disease across age.Neurobiology of aging · 2019Article
- Exome sequencing in a familial form of anorexia nervosa supports multigenic etiology.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program.Nature communications · 2019Observational
- Genetic variants related to urate and risk of Parkinson's disease.Parkinsonism & related disorders · 2018Article
- An update on the genetics of hyperuricaemia and gout.Nature reviews. Rheumatology · 2018Review
- Genetic variants in two pathways influence serum urate levels and gout risk: a systematic pathway analysis.Scientific reports · 2018Article
- Heritability and Genome-Wide Association Analyses of Serum Uric Acid in Middle and Old-Aged Chinese Twins.Frontiers in endocrinology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
120 authors at 20 institutions in 13 countries.
Jennifer E HuffmanMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
Eva AlbrechtInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Alexander TeumerInterfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
Massimo ManginoKing's College London, St. Thomas' Hospital Campus, London, United Kingdom.
Karen KapurDepartment of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Toby JohnsonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Zoltán KutalikDepartment of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Nicola PirastuInstitute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy.
Giorgio PistisDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy.
Lorna M LopezDepartment of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
Toomas HallerEstonian Genome Center, University of Tartu, Tartu, Estonia.
Perttu SaloDepartment of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland.
Anuj GoelDepartment of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Man LiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
Toshiko TanakaClinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America.
Abbas DehghanMember of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Daniela RuggieroInstitute of Genetics and Biophysics "A. Buzzati-Traverso"-Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
Giovanni MalerbaBiology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
Albert V SmithIcelandic Heart Association Research Institute, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
Ilja M NolteDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Laura PortasInstitute of Population Genetics, National Research Council of Italy, Sassari, Italy.
Amanda Phipps-GreenDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Lora BotevaMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
Pau NavarroMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
Asa JohanssonUppsala Clinical Research Center, Uppsala University Hospital, Upsalla, Sweden; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden.
Andrew A HicksCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy; Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Ozren PolasekFaculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia; Broad Institute, Cambridge, MA, United States of America; Children's Hospital Boston, Boston, MA, United States of America.
John F PedenDepartment of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom; Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom.
Federico MurgiaInstitute of Population Genetics, National Research Council of Italy, Sassari, Italy.
Sarah H WildInstitute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Albert TenesaMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom; Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Adrienne TinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu, Estonia.
Anne GrotevendtInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.
Gauti K GislasonIcelandic Heart Association Research Institute, Kopavogur, Iceland.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, MD, United States of America.
Pio D'AdamoInstitute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy.
Sheila UliviInstitute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy.
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Gerard WaeberDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Susan CampbellMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
Ivana KolcicFaculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia.
Krista FisherEstonian Genome Center, University of Tartu, Tartu, Estonia.
Margus ViigimaaTallinn University of Technology, Department of Biomedical Engineering, Chair of Medical Physics, Tallinn, Estonia; Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia.
Jeffrey E MetterClinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America.
Corrado MasciulloDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy.
Elisabetta TrabettiBiology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
Cristina BombieriBiology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
Rossella SoriceInstitute of Genetics and Biophysics "A. Buzzati-Traverso"-Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
Angela DöringInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Eva ReischlInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany.
Albert HofmanMember of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Andre G UitterlindenMember of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Melanie WaldenbergerInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
H-Erich WichmannInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany; Klinikum Grosshadern, Munich, Germany.
Gail DaviesDepartment of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
Alan J GowDepartment of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
Nicola DalbethBone and Joint Research Group, Department of Medicine, University of Auckland, Auckland, New Zealand.
Lisa StampDepartment of Medicine, University of Otago, Christchurch, New Zealand.
Johannes H SmitDepartment of Psychiatry/EMGO Institute, VU University Medical Centre, Amsterdam, the Netherlands.
Mirna KirinInstitute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Ramaiah NagarajaLaboratory of Genetics, National Institute on Aging (NIA), Baltimore, MD, United States of America.
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.
Claudia SchurmannInterfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
Kathrin BuddeInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.
Susan M FarringtonMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
Evropi TheodoratouInstitute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Antti JulaDepartment of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Turku, Finland.
Veikko SalomaaDepartment of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland.
Cinzia SalaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy.
Christian HengstenbergUniversity Hospital Regensburg, Regensburg, Germany.
Michel BurnierDepartment of Medicine, Nephrology Division, Lausanne University Hospital, Lausanne, Switzerland.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Norman KloppInstitute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany.
Stefan KloiberMax Planck Institute of Psychiatry, Munich, Germany.
Sabine SchipfInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Samuli RipattiDepartment of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Turku, Finland; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom; University of Helsinki, Institute of Molecular Medicine, Helsinki, Finland.
Stefano CabrasDepartment of Mathematics and Informatics, Università di Cagliari, Cagliari, Italy; Department of Statistics, Universidad Carlos III de Madrid, Madrid, Spain.
Nicole SoranzoHuman Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
Teresa NutileInstitute of Genetics and Biophysics "A. Buzzati-Traverso"-Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
Patricia B MunroeWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Nicholas HastieMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
Harry CampbellInstitute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Igor RudanFaculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia; Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Claudia CabreraQueen Mary, University of London, London, United Kingdom.
Chris HaleyMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom; Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Oscar H FrancoMember of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Tony R MerrimanDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Vilmundur GudnasonIcelandic Heart Association Research Institute, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
Mario PirastuInstitute of Population Genetics, National Research Council of Italy, Sassari, Italy.
Brenda W PenninxDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Department of Epidemiology, Subdivision Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Harold SniederDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Marina CiulloInstitute of Genetics and Biophysics "A. Buzzati-Traverso"-Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
Peter P PramstallerCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy; Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Cornelia M van DuijnDepartment of Epidemiology, Subdivision Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Luigi FerrucciClinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America.
Giovanni GambaroInstitute of Internal Medicine, Renal Program, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy.
Ian J DearyDepartment of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
Malcolm G DunlopMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
James F WilsonInstitute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Paolo GaspariniInstitute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy.
Ulf GyllenstenDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden.
Tim D SpectorKing's College London, St. Thomas' Hospital Campus, London, United Kingdom.
Alan F WrightMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
Caroline HaywardMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
Hugh Watkinson behalf of PROCARDIS; Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Markus PerolaEstonian Genome Center, University of Tartu, Tartu, Estonia; Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland; University of Helsinki, Institute of Molecular Medicine, Helsinki, Finland.
Murielle BochudUniversity Institute of Social and Preventive Medicine, Lausanne, Switzerland.
W H Linda KaoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, MD, United States of America.
Mark CaulfieldWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Daniela TonioloDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Anna KöttgenDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Renal Division, Freiburg University Hospital, Freiburg, Germany.
Veronique VitartMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
University of Edinburgh · GBMRC Institute of Genetics and Molecular Medicine · GBUniversity of Tartu · EEHelmholtz Zentrum München · DEUniversitätsmedizin Greifswald · DEInstitute of Genetics and Biophysics · ITJohns Hopkins University · USNational Institute on Aging · USUniversity of Lausanne · CHErasmus MC · NLFinnish Institute for Health and Welfare · FILudwig-Maximilians-Universität München · DENational Research Council · ITUniversität Greifswald · DEUniversity of Otago · NZUniversity of Verona · ITWilliam Harvey Research Institute · GBErasmus University Rotterdam · NLIstituti di Ricovero e Cura a Carattere Scientifico · ITMedical Research Council · GB
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MThe Aging Genome Association Study "AGE-GAIN"ZIAAG000965 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$4.0MGenome-Wide Association for Loci Influencing CHD and Other Heart, Lung and BloodR01HL087641 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2006 to 2008
$3.7MHISPANIC SECONDARY STROKE PREVENTION INITIATIVER01MD009164 · NIMHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN · 2014 to 2018
$1.9MGWA for Gene-Environment Interaction Effects Influencing CHDU01HG004402 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2007 to 2009
$1.6MAGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
–Biotechnology and Biological Sciences Research Council BB/F019394/1Cancer Research UK 12076Cancer Research UK C348/A12076Cancer Research UK C348/A6361Medical Research Council G0000657-53203Medical Research Council G0700704Medical Research Council G9521010Medical Research Council G9521010DMedical Research Council MC_PC_U127527198Medical Research Council MC_PC_U127561128Medical Research Council MC_PC_U127592696Medical Research Council MR/K006584/1Medical Research Council MR/K018647/1Medical Research Council MR/K026992/1NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01HL59367NIA NIH HHS N01 AG012100NIA NIH HHS N01-AG-12100NIMHD NIH HHS R01 MD009164PHS HHS HHSN268200625226CWellcome Trust 095831
Abstract
We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, Pinter= 2.6 x 10-8). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDARADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10-8), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10-8), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10-4). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.
Indexed as
Antigens, NuclearATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2Body Mass IndexEdar ReceptorFemaleGenetic LociGenome-Wide Association StudyGenotypeGoutHumansLinear ModelsMaleMembrane GlycoproteinsNeoplasm ProteinsNerve Tissue ProteinsABCG2 protein, humanAntigens, NuclearATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2EDAR protein, humanEdar ReceptorERO1B protein, humanMembrane GlycoproteinsNeoplasm ProteinsNerve Tissue Proteinsneuronal nuclear antigen NeuN, humanOxidoreductases Acting on Sulfur Group DonorsUric Acid
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC0
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.