ArticleThe journal of physical chemistry. B2015
Improving the hyperpolarization of (31)P nuclei by synthetic design.
Article in The journal of physical chemistry. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Scalable modeling of multi-spin ensembles in SABRE hyperpolarization: a symmetry-based framework for zero and ultralow fields.Magnetic resonance (Gottingen, Germany) · 2026Article
- High HThe journal of physical chemistry letters · 2025Article
- Enhancing the NMR signals of plant oil components using hyperpolarisation relayedChemical science · 2023Article
- Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives.International journal of molecular sciences · 2022Article
- Multiaxial fields improve SABRE efficiency by preserving hydride order.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- SABRE enhancement with oscillating pulse sequences.Physical chemistry chemical physics : PCCP · 2022Article
- Analysis of Complex Mixtures by Chemosensing NMR UsingAccounts of chemical research · 2022Article
- Real-Time High-Sensitivity Reaction Monitoring of Important Nitrogen-Cycle Synthons byJournal of the American Chemical Society · 2022Article
- Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications.Chemical science · 2022Review
- Improving SABRE hyperpolarization with highly nonintuitive pulse sequences: Moving beyond avoided crossings to describe dynamics.Science advances · 2022Article
- Article
- Synthesis andChemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Zero-Field NMRThe journal of physical chemistry letters · 2021Article
- Reversible Hyperpolarization of Ketoisocaproate Using Sulfoxide-containing Polarization Transfer Catalysts.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Parahydrogen-Induced Hyperpolarization of Gases.Angewandte Chemie (International ed. in English) · 2020Review
- Acquisition strategies for spatially resolved magnetic resonance detection of hyperpolarized nuclei.Magma (New York, N.Y.) · 2020Review
- Optimisation of pyruvate hyperpolarisation using SABRE by tuning the active magnetisation transfer catalyst.Catalysis science & technology · 2020Article
- Low-Concentration Measurements of Nuclear Spin-Induced Optical Rotation Using SABRE Hyperpolarization.The journal of physical chemistry letters · 2019Article
- Article
- Using coligands to gain mechanistic insight into iridium complexes hyperpolarized withChemical science · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
Traditional (31)P NMR or MRI measurements suffer from low sensitivity relative to (1)H detection and consequently require longer scan times. We show here that hyperpolarization of (31)P nuclei through reversible interactions with parahydrogen can deliver substantial signal enhancements in a range of regioisomeric phosphonate esters containing a heteroaromatic motif which were synthesized in order to identify the optimum molecular scaffold for polarization transfer. A 3588-fold (31)P signal enhancement (2.34% polarization) was returned for a partially deuterated pyridyl substituted phosphonate ester. This hyperpolarization level is sufficient to allow single scan (31)P MR images of a phantom to be recorded at a 9.4 T observation field in seconds that have signal-to-noise ratios of up to 94.4 when the analyte concentration is 10 mM. In contrast, a 12 h 2048 scan measurement under standard conditions yields a signal-to-noise ratio of just 11.4. (31)P-hyperpolarized images are also reported from a 7 T preclinical scanner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.