ArticleIranian journal of basic medical sciences2015
Antihypertensive effect of auraptene, a monoterpene coumarin from the genus Citrus, upon chronic administration.
Article in Iranian journal of basic medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 34 citations in OpenAlex.
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- Article
- Possible involvement of L-arginine-nitric oxide pathway in the antidepressant activity of Auraptene in mice.Behavioral and brain functions : BBF · 2022Article
- Neuroprotective Potential of Limonene and Limonene Containing Natural Products.Molecules (Basel, Switzerland) · 2021Review
- Novel nano-vehicle for delivery and efficiency of anticancer auraptene against colon cancer cells.Scientific reports · 2020Article
- The Protective Effect of Auraptene Against Oxidative Stress and Pentylenetetrazol-Induced Chemical Kindling in Mice.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Ethyl Acetate Fraction ofOxidative medicine and cellular longevity · 2019Article
- Cardiovascular Activity of the Chemical Constituents of Essential Oils.Molecules (Basel, Switzerland) · 2017Review
- Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis.Molecules (Basel, Switzerland) · 2017Article
- Phytochemistry and pharmacology ofIranian journal of basic medical sciences · 2017Review
- Auraptene consolidates memory, reverses scopolamine-disrupted memory in passive avoidance task, and ameliorates retention deficits in mice.Iranian journal of basic medical sciences · 2015Article
- Phytochemical and Therapeutic Potential ofJournal of evidence-based integrative medicineReview
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAuraptene, a monoterpene coumarin from Citrus species, exhibits cardioprotective effects. In this study, the effects of auraptene administration were investigated on blood pressure of normotensive and desoxycorticosterone acetate (DOCA) salt induced hypertensive rats. MATERIALS AND
methodsFive weeks administration of auraptene (2, 4, 8 and 16 mg/kg/day) and nifedipine (0.25, 0.5, 1, 2 and 4 mg/kg/day) in different groups of normotensive and hypertensive rats (at the end of 3 weeks treatment by DOCA salt) was carried out and their effects on mean systolic blood pressure (MSBP) and mean heart rate (MHR) were evaluated using tail cuff method.
resultsOur results indicated that chronic administration of auraptene (2, 4, 8 and 16 mg/kg/day) significantly reduced the MSBP in DOCA salt treated rats in a dose and time dependent manner. The percent of decreases in MSBP levels by the highest dose of auraptene (16 mg/kg) at the end of 4 (th) to 8 (th) weeks, were 7.00%, 10.78%, 16.07%, 21.28% and 27.54% respectively (P<0.001). Moreover the antihypertensive effect of auraptene was less than nifedipine (ED50 value of nifedipine = 0.7 mg/kg at 8(th) week and ED50 value of auraptene = 5.64 mg/kg at 8 week).
conclusionAuraptene considerably reduced MSBP in hypertensive rats, but not in normotensive (normal saline treated) rats. The results of MHR measurement showed that the increase in MHR was not significant in comparison with DOCA treated rats.
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25810889PMC4366726W2171903578What OpenQuestion holds
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