ReviewJournal of clinical and experimental dentistry2015
Graft-versus-host disease affecting oral cavity. A review.
Review in Journal of clinical and experimental dentistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease.Medicina oral, patologia oral y cirugia bucal · 2019Trial
- Cell-mediated mucositis of the oral cavity: narrative review on etiology, clinico-pathological aspects and malignant transformation.Pathologica · 2025Review
- Oral GVHD post-cardiac xenograft valve replacement: a case report.Journal of cardiothoracic surgery · 2024Article
- Salivary gland function, development, and regeneration.Physiological reviews · 2022Review
- Oral manifestations of graft-versus-host disease in patients submitted to allogeneic hematopoietic stem cell transplantation: the experience of a Brazilian Cancer Center.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Observational
- Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer.Frontiers in pharmacology · 2022Review
- Oral Dysplastic Complications after HSCT: Single Case Series of Multidisciplinary Evaluation of 80 Patients.Life (Basel, Switzerland) · 2020Article
- Evaluation of treatment response in oral chronic graft-versus-host patients by power doppler ultrasound: a prospective study.Dento maxillo facial radiology · 2020Article
- Small Opening, Big Problem: Esophageal Food Bolus Impaction and Microstomia.ACG case reports journal · 2019Article
- Changes in body composition in children with acute graft-versus-host disease within the first 100 days after hematopoietic stem cell transplantation.European journal of clinical nutrition · 2018Article
- An Unusual Cause of Dysphagia.Dysphagia · 2016Article
- Pre-transplant arm muscle area: a simple measure to identify patients at risk.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Dentistry consensus on HSCT - Part III: Special topics - Dentistry on HSCT.Hematology, transfusion and cell therapyReview
- Dental and ENT Evaluation Before Liver Transplantation.Journal of clinical and experimental hepatologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graft versus host disease (GVHD) is one of the most frequent and serious complications of hematopoietic stem cell transplantation, and is regarded as the leading cause of late mortality unrelated to the underlying malignant disease. GVHD is an autoimmune and alloimmune disorder that usually affects multiple organs and tissues, and exhibits a variable clinical course. It can manifest in either acute or chronic form. The acute presentation of GVHD is potentially fatal and typically affects the skin, gastrointestinal tract and liver. The chronic form is characterized by the involvement of a number of organs, including the oral cavity. Indeed, the oral cavity may be the only affected location in chronic GVHD. The clinical manifestations of chronic oral GVHD comprise lichenoid lesions, hyperkeratotic plaques and limited oral aperture secondary to sclerosis. The oral condition is usually mild, though moderate to severe erosive and ulcerated lesions may also be seen. The diagnosis is established from the clinical characteristics, though confirmation through biopsy study is sometimes needed. Local corticosteroids are the treatment of choice, offering overall response rates of close to 50%. Extracorporeal photopheresis and systemic corticosteroids in turn constitute second line treatment. Oral chronic GVHD is not considered a determinant factor for patient survival, which is close to 52% five years after diagnosis of the condition. Key words:Chronic graft-versus-host disease, oral chronic graft-versus-host disease, pathogenics, management, survival.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.