ArticleJournal of neurodevelopmental disorders2015
Psychiatric disorders in adolescents and young adults with Down syndrome and other intellectual disabilities.
Article in Journal of neurodevelopmental disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Neuropsychiatric decompensation in adolescents and adults with Phelan-McDermid syndrome: a systematic review of the literature.Molecular autism · 2019Pooled it
- Feasibility study of a parent-driven intervention for youth with Down syndrome.Journal of intellectual disability research : JIDR · 2024Trial
- Comparative language performance in children and adolescents with 22q11.2ds syndrome and down syndrome.Journal of neurodevelopmental disorders · 2026Article
- Adapting a Behavioral Intervention for Caregivers of Children with Down Syndrome or Fragile X Syndrome: A Pilot Study of RUBI-DD.Behavioral sciences (Basel, Switzerland) · 2026Article
- Risk of depressive and anxiety disorders in young adults with disabilities: a nationwide cohort study in South Korea.Epidemiology and psychiatric sciences · 2026Article
- Transdiagnostic determinants of access to mental health care for youth with disabilities: a systems-oriented structured narrative review.Frontiers in public health · 2026Review
- Retrospective Reports of Skill Attainment and Loss in Phelan-McDermid Syndrome.American journal on intellectual and developmental disabilities · 2025Article
- The Use of the Anxiety, Depression and Mood Scale (ADAMS) as a Screening Instrument for Depression and Mental Health Diagnoses in a Down Syndrome Specialty Clinic.Journal of applied research in intellectual disabilities : JARID · 2025Article
- Neuronal oscillations in cognition: Down syndrome as a model of mouse to human translation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- The state of anxiety treatments for adolescents and adults down syndrome: Results from a scoping rapid review.Journal of mood and anxiety disorders · 2024Review
- Behavioral and Psychiatric Disorders in Syndromic Autism.Brain sciences · 2024Review
- Health care transition quadruple aim outcomes for IDD: Scoping review.Health care transitions · 2024Article
- Schizophrenia in children, adults and older people with intellectual disability compared with the general population: a Swedish register study (IDcare).General psychiatry · 2024Article
- Exploring the link between hedonic overeating and prefrontal cortex dysfunction in the Ts65Dn trisomic mouse model.Cellular and molecular life sciences : CMLS · 2023Article
- Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture.iScience · 2023Article
- Physical Activity and Physical and Mental Health in Middle-Aged Adults with Down Syndrome.Journal of policy and practice in intellectual disabilities · 2022Article
- Delusion of Pregnancy in Down Syndrome: Two Case Reports.International journal of environmental research and public health · 2022Article
- Oral Hygiene Practices among Adults with Intellectual Disabilities-A Pilot Study.Dentistry journal · 2022Article
- Fatty Acids: A Safe Tool for Improving Neurodevelopmental Alterations in Down Syndrome?Nutrients · 2022Review
- Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome.Disability and health journal · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRelative to other aspects of Down syndrome, remarkably little is known about the psychiatric problems experienced by youth and young adults with this syndrome and if these problems differ from others with intellectual disabilities. Yet adolescence and young adulthood are particularly vulnerable time periods, as they involve multiple life transitions in educational, medical, and other service systems.
methodsThis study compared the psychiatric diagnoses of 49 adolescent and young adult patients with Down syndrome to 70 patients with other intellectual disabilities (IDs). The groups were similar in age, gender, and level of intellectual impairment. The 119 participants, aged 13 to 29 years (M = 21) were evaluated in one of two specialized psychiatric clinics.
resultsIn contrast to previous literature, those with Down syndrome versus other IDs had significantly higher rates of psychosis NOS or depression with psychotic features (43% versus 13%). Unlike the ID group, psychosis was predominantly seen in females with Down syndrome. Marked motoric slowing in performing routine daily activities or in expressive language was manifested in 17% of patients with Down syndrome. No group differences were found in anxiety or depressive disorders, and the ID group had significantly higher rates of bipolar and impulse control disorders.
conclusionsThese preliminary observations warrant further studies on genetic, neurological, and psychosocial factors that place some young people with Down syndrome or other IDs at high risk for severe psychiatric illness.
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